Chemical Modification of Pullulan Exopolysaccharide by Grafting Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) via Click Chemistry

Autor(es)

T. de Carvalho, Layde ^[1] ; da S. Paula, Maria Luiza ^[1] ; M. de Moraes, Rodolfo ^[1] ; Alves, Gizelda M. ^[1] ; M. Lacerda, Talita ^[2] ; dos Santos, Julio C. ^[2] ; M. dos Santos, Amilton ^[1] ; Medeiros, Simone de F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Engn Sch Lorena, Dept Chem Engn, EEL USP, BR-12602810 Lorena, SP - Brazil

^[2] Univ Sao Paulo, Engn Sch Lorena, Dept Biotechnol, BR-12602810 Lorena, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: POLYMERS; v. 12, n. 11 NOV 2020.
• Citações Web of Science: 0

Resumo

Biodegradable and biocompatible copolymers have been often studied for the development of biomaterials for drug delivery systems. In this context, this work reports the synthesis and characterization of a novel pullulan-g-poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (Pull-g-PHBHV) graft copolymer using click chemistry. Well-defined and functional pullulan backbones containing azide groups (PullN(3)) previously prepared by our group were successfully used for this purpose and propargyl-terminated poly(3-hydroxybutyrate-co-3-hydroxyvalerate) was prepared via transesterification using propargyl alcohol as a chain transfer agent. By an alkyne-azide cycloaddition reaction catalyzed by copper (Cu (I)) (CuAAC), the graft copolymer Pull-g-PHBHV was obtained. The chemical structures of the polymers were accessed by H-1 NMR and C-13 NMR FTIR. Disappearance of the bands referring to the main bonds evidenced success in the grafting reaction. Besides that, DRX, DSC and TGA were used in order to access the changes in crystallinity and thermal behavior of the material. The remaining crystallinity of the Pull-g-PHBHV structure evidences the presence of PHBHV. Pull-g-PHBHV presented lower degradation maximum temperature values than the starting materials, indicating its minor thermal stability. Finally, the synthesized material is an innovative biopolymer, which has never been reported in the previous literature. It is a bio-derived and biodegradable polymer, chemically modified, resulting in interesting properties which can be useful for their further applications as biomedical systems for controlled delivery, for example. (AU)

• Processo FAPESP: 19/04269-0 - Avaliação do potencial de novas nanopartículas poliméricas como agentes de encapsulação e liberação simultânea de um agente fotossensibilizador e um princípio ativo quimioterápico
• Beneficiário: Simone de Fátima Medeiros Sampaio
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/10616-2 - Modificação química do exopolissacarídeo pululana através da enxertia de poli(3-hidroxibutirato-co-3-hidroxivalerato) (PHBHV) via click chemistry
• Beneficiário: Simone de Fátima Medeiros Sampaio
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo