Biosensing on the Centrifugal Microfluidic Lab-on-a-Disc Platform

Autor(es)

Miyazaki, Celina M. ^[1] ; Carthy, Eadaoin ^[2] ; Kinahan, David J. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Ctr Sci & Technol Sustainabil, BR-18052780 Sorocaba, SP - Brazil

^[2] Dublin City Univ, Sch Mech & Mfg Engn, Dublin 9 - Ireland

• Tipo de documento: Artigo de Revisão
• Fonte: PROCESSES; v. 8, n. 11 NOV 2020.
• Citações Web of Science: 0

Resumo

Lab-on-a-Disc (LoaD) biosensors are increasingly a promising solution for many biosensing applications. In the search for a perfect match between point-of-care (PoC) microfluidic devices and biosensors, the LoaD platform has the potential to be reliable, sensitive, low-cost, and easy-to-use. The present global pandemic draws attention to the importance of rapid sample-to-answer PoC devices for minimising manual intervention and sample manipulation, thus increasing the safety of the health professional while minimising the chances of sample contamination. A biosensor is defined by its ability to measure an analyte by converting a biological binding event to tangible analytical data. With evolving manufacturing processes for both LoaDs and biosensors, it is becoming more feasible to embed biosensors within the platform and/or to pair the microfluidic cartridges with low-cost detection systems. This review considers the basics of the centrifugal microfluidics and describes recent developments in common biosensing methods and novel technologies for fluidic control and automation. Finally, an overview of current devices on the market is provided. This review will guide scientists who want to initiate research in LoaD PoC devices as well as providing valuable reference material to researchers active in the field. (AU)

• Processo FAPESP: 14/15093-7 - Estudos de sistemas nanoestruturados por ressonância plasmônica de superfície (SPR): aplicações em biossensoriamento
• Beneficiário: Celina Massumi Miyazaki
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/16311-0 - Detecção altamente paralelizada de bioamostras por SPR em uma plataforma microfluídica integrada para análises em larga escala
• Beneficiário: Celina Massumi Miyazaki
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado