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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biosensing on the Centrifugal Microfluidic Lab-on-a-Disc Platform

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Author(s):
Miyazaki, Celina M. [1] ; Carthy, Eadaoin [2] ; Kinahan, David J. [2]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Carlos, Ctr Sci & Technol Sustainabil, BR-18052780 Sorocaba, SP - Brazil
[2] Dublin City Univ, Sch Mech & Mfg Engn, Dublin 9 - Ireland
Total Affiliations: 2
Document type: Review article
Source: PROCESSES; v. 8, n. 11 NOV 2020.
Web of Science Citations: 0
Abstract

Lab-on-a-Disc (LoaD) biosensors are increasingly a promising solution for many biosensing applications. In the search for a perfect match between point-of-care (PoC) microfluidic devices and biosensors, the LoaD platform has the potential to be reliable, sensitive, low-cost, and easy-to-use. The present global pandemic draws attention to the importance of rapid sample-to-answer PoC devices for minimising manual intervention and sample manipulation, thus increasing the safety of the health professional while minimising the chances of sample contamination. A biosensor is defined by its ability to measure an analyte by converting a biological binding event to tangible analytical data. With evolving manufacturing processes for both LoaDs and biosensors, it is becoming more feasible to embed biosensors within the platform and/or to pair the microfluidic cartridges with low-cost detection systems. This review considers the basics of the centrifugal microfluidics and describes recent developments in common biosensing methods and novel technologies for fluidic control and automation. Finally, an overview of current devices on the market is provided. This review will guide scientists who want to initiate research in LoaD PoC devices as well as providing valuable reference material to researchers active in the field. (AU)

FAPESP's process: 14/15093-7 - Study of nanostructured systems by surface plasmon resonance (SPR): applications in biosensing
Grantee:Celina Massumi Miyazaki
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/16311-0 - Highly parallelised SPR detection of biosamples on a large-scale-integrated microfluidic platform
Grantee:Celina Massumi Miyazaki
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor