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Busatto Filho, Geraldo ^[1] ; Duran, Fabio Luiz de Souza ^[1] ; Squarzoni, Paula ^[1] ; Coutinho, Artur Martins Novaes ^[2] ; Rosa, Pedro Gomes Penteado ^[1] ; Torralbo, Leticia ^[1] ; Pachi, Clarice Gameiro da Fonseca ^[1] ; da Costa, Naomi Antunes ^[1] ; Porto, Fabio Henrique de Gobbi ^[1] ; Carvalho, Cleudiana Lima ^[1] ; Brucki, Sonia Maria Dozzi ^[3] ; Nitrini, Ricardo ^[3] ; Forlenza, Orestes Vicente ^[4] ; Leite, Claudia da Costa ^[5] ; Buchpiguel, Carlos Alberto ^[2] ; de Paula Faria, Daniele ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, Fac Med FMUSP, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Radiol & Oncol, Lab Nucl Med LIM43, Fac Med FMUSP, Ctr Nucl Med Bldg, 2nd Floor, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Dept Neurol, Fac Med FMUSP, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Psychiat, Lab Neurosci LIM 27, Fac Med FMUSP, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Dept Radiol & Oncol, Lab Magnet Resonance Neuroradiol LIM44, Fac Med FMUSP, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Neuroscience Research; v. 99, n. 2, p. 481-501, FEB 2021.
• Citações Web of Science: 0

Resumo

Changes in hippocampal subfield volumes (HSV) along the Alzheimer's disease (AD) continuum have been scarcely investigated to date in elderly subjects classified based on the presence of beta-amyloid aggregation and signs of neurodegeneration. We classified patients (either sex) with mild dementia compatible with AD (n = 35) or amnestic mild cognitive impairment (n = 39), and cognitively unimpaired subjects (either sex;n = 26) using {[}C-11]PIB-PET to assess beta-amyloid aggregation (A+) and {[}F-18]FDG-PET to account for neurodegeneration ((N)+). Magnetic resonance imaging-based automated methods were used for HSV and white matter hyperintensity (WMH) measurements. Significant HSV reductions were found in A+(N)+ subjects in the presubiculum/subiculum complex and molecular layer, related to worse memory performance. In both the A+(N)+ and A+(N)- categories, subicular volumes were inversely correlated with the degree of A beta deposition. The A-(N)+ subgroup showed reduced HSV relative to the A-(N)- subgroup also in the subiculum/presubiculum. Combining all (N)- subjects, HSV were lower in subjects presenting significant cognitive decline irrespective of A+/A- classification (controlling for WMH load); these between-group differences were detected again in the presubiculum, but also involved the CA4 and granular layer. These findings demonstrate that differential HSV reductions are detectable both in (N)+ and (N)- categories along the AD continuum, and are directly related to the severity of cognitive deficits. HSV reductions are larger both in A+(N)+ and A+(N)- subjects in direct proportion to the degree of A beta deposition. The meaningful HSV reductions detected in the A-(N)+ subgroup highlights the strength of biomarker-based classifications outside of the classical AD continuum. (AU)

• Processo FAPESP: 18/15167-1 - Neuroimagem translacional na deficiência intelectual: avaliação de alterações moleculares associadas ao envelhecimento na Síndrome de Down
• Beneficiário: Daniele de Paula Faria
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores