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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hippocampal subregional volume changes in elders classified using positron emission tomography-based Alzheimer's biomarkers of beta-amyloid deposition and neurodegeneration

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Busatto Filho, Geraldo [1] ; Duran, Fabio Luiz de Souza [1] ; Squarzoni, Paula [1] ; Coutinho, Artur Martins Novaes [2] ; Rosa, Pedro Gomes Penteado [1] ; Torralbo, Leticia [1] ; Pachi, Clarice Gameiro da Fonseca [1] ; da Costa, Naomi Antunes [1] ; Porto, Fabio Henrique de Gobbi [1] ; Carvalho, Cleudiana Lima [1] ; Brucki, Sonia Maria Dozzi [3] ; Nitrini, Ricardo [3] ; Forlenza, Orestes Vicente [4] ; Leite, Claudia da Costa [5] ; Buchpiguel, Carlos Alberto [2] ; de Paula Faria, Daniele [2]
Total Authors: 16
Affiliation:
[1] Univ Sao Paulo, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, Fac Med FMUSP, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Radiol & Oncol, Lab Nucl Med LIM43, Fac Med FMUSP, Ctr Nucl Med Bldg, 2nd Floor, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Neurol, Fac Med FMUSP, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Psychiat, Lab Neurosci LIM 27, Fac Med FMUSP, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Radiol & Oncol, Lab Magnet Resonance Neuroradiol LIM44, Fac Med FMUSP, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Neuroscience Research; v. 99, n. 2, p. 481-501, FEB 2021.
Web of Science Citations: 0
Abstract

Changes in hippocampal subfield volumes (HSV) along the Alzheimer's disease (AD) continuum have been scarcely investigated to date in elderly subjects classified based on the presence of beta-amyloid aggregation and signs of neurodegeneration. We classified patients (either sex) with mild dementia compatible with AD (n = 35) or amnestic mild cognitive impairment (n = 39), and cognitively unimpaired subjects (either sex;n = 26) using {[}C-11]PIB-PET to assess beta-amyloid aggregation (A+) and {[}F-18]FDG-PET to account for neurodegeneration ((N)+). Magnetic resonance imaging-based automated methods were used for HSV and white matter hyperintensity (WMH) measurements. Significant HSV reductions were found in A+(N)+ subjects in the presubiculum/subiculum complex and molecular layer, related to worse memory performance. In both the A+(N)+ and A+(N)- categories, subicular volumes were inversely correlated with the degree of A beta deposition. The A-(N)+ subgroup showed reduced HSV relative to the A-(N)- subgroup also in the subiculum/presubiculum. Combining all (N)- subjects, HSV were lower in subjects presenting significant cognitive decline irrespective of A+/A- classification (controlling for WMH load); these between-group differences were detected again in the presubiculum, but also involved the CA4 and granular layer. These findings demonstrate that differential HSV reductions are detectable both in (N)+ and (N)- categories along the AD continuum, and are directly related to the severity of cognitive deficits. HSV reductions are larger both in A+(N)+ and A+(N)- subjects in direct proportion to the degree of A beta deposition. The meaningful HSV reductions detected in the A-(N)+ subgroup highlights the strength of biomarker-based classifications outside of the classical AD continuum. (AU)

FAPESP's process: 18/15167-1 - Translational neuroimaging in intellectual disability: evaluation of molecular changes associated with aging in Down Syndrome
Grantee:Daniele de Paula Faria
Support Opportunities: Research Grants - Young Investigators Grants