Association of Adipocytokines and Inflammatory Biomarkers with Blood Pressure in Adolescents: A Longitudinal Analysis

Autor(es)

Agostinis-Sobrinho, Cesar ^[1] ; Ramirez-Velez, Robinson ^[2] ; Norkiene, Sigute ^[1] ; Damaso, Ana ^[3] ; Ganen, Aline de Piano ^{[1, 4]} ; Landi Masquio, Deborah C. ^{[1, 4]} ; Rauckien-Michaelsson, Alona ^[1] ; Mota, Jorge ^[5] ; Santos, Rute ^[5]

Afiliação do(s) autor(es)

^[1] Klaipeda Univ, Fac Hlth Sci, Herkaus Manto G 84, LT-92294 Klaipeda - Lithuania

^[2] Univ Publ Navarra UPNA Navarrabiomed, Inst Invest Sanitaria Navarra IdiSNA, Complejo Hosp Navarra CHN, Pamplona 31008, Navarra - Spain

^[3] Univ Fed Sao Paulo, Paulista Med Sch Grad Program Nutr, Sao Paulo, SP - Brazil

^[4] Sao Camilo Univ Ctr, Nutr Birth Adolescence, Sao Paulo, SP - Brazil

^[5] Univ Porto, Res Ctr Phys Act Hlth & Leisure, Fac Sport, Porto - Portugal

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES; v. 30, n. 12, p. 2296-2302, NOV 27 2020.
• Citações Web of Science: 0

Resumo

Background and aims: Several cross-sectional, but few prospective, studies suggest that inflammation may be involved in the development of high blood pressure. We examined markers of inflammation for their associations with blood pressure levels over a two-year period in healthy adolescents. Methods and results: The sample comprised 406 adolescents (209 girls) aged 12-18 years in the LabMed Physical Activity Study were followed-up for 2 years. Anthropometric (weigh, height, BMI), markers of inflammation (high sensitivity C-reactive protein, complement factors C3 and C4, fibrinogen, leptin and adiponectin) and ambulatory blood pressure (BP) were collected. Socioeconomic status, pubertal development, adherence to Mediterranean diet and cardiorespiratory fitness were measured for adjustment for potential confounders. Adjusted linear regression models revealed a significant association of Leptin/Adiponectin (L/A) Ratio (baseline) with systolic BP (beta = 0.120; p < 0.034) and with diastolic BP (beta = 0.125; p < 0.036) at follow-up (full adjusted model). Leptin was associated with systolic BP at follow-up (beta = 0.102; p < 0.038) after adjustment for systolic BP at baseline, height, pubertal stage, socioeconomic status, adherence to Mediterranean diet, cardiorespiratory fitness, however, not independently of BMI. Conclusion: L/A ratio was positively associated with systolic BP and diastolic BP even after adjusting confounding variables. Therefore, a higher misbalance between leptin and adiponectin (higher L/A ratio) early adolescence may exert a negative effect BP levels in late adolescence regardless of several confounders factors. (C) 2020 Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. (AU)

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