Chemokine expression profiles in liver and kidney of mice with different susceptibilities to leptospirosis

Autor(es)

Silva, Paloma L. D. ^[1] ; Nakajima, Erika ^[2] ; da Costa, Renata M. A. ^[3] ; Ho, Paulo Lee ^[4] ; Martins, Elizabeth A. L. ^[2] ; Carvalho, Eneas ^[1] ; da Silva, Josefa B. ^[1]

Afiliação do(s) autor(es)

^[1] Inst Butantan, Lab Bacteriol, Sao Paulo - Brazil

^[2] Inst Butantan, Lab Biol Recombinantes, Sao Paulo - Brazil

^[3] Global Antibiot Res & Dev Partnership GARDP, Drugs Neglected Dis Initiat DNDi, Chemin Louis Dunant 15, CH-1202 Geneva - Switzerland

^[4] Inst Butantan, Div Bioind, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Microbial Pathogenesis; v. 149, DEC 2020.
• Citações Web of Science: 1

Resumo

Leptospirosis is a global disease that affects humans and animals, impacting public health and the economy. The symptoms caused by Leptospira infection can vary from mild to severe, affecting liver, lungs, and kidneys. The host-pathogen interaction in leptospirosis is still poorly understood, but there is evidence for the role of the host immune response in the pathogenesis. Chemokines are a family of structurally-related low-molecular-mass proteins (8-14 kDa) that signal the recruitment of leukocytes. In this study the profile of 22 chemokines were evaluated in liver and kidney of three mice strains with different phenotypes of susceptibility to leptospirosis. We extended our previously reported observations showing that expression of chemokines with homeostatic function, activation and chemotaxis of leukocytes are essential to modulate and to induce resistance to leptospirosis. Our findings support that an early induction of CXC chemokines in resistant BALB/c mice can be associated with the control of the infection. The correlation of chemokine expression between liver and kidney observed in BALB/c suggests that a balance of chemokine induction in the organs may contribute to resistance to leptospirosis. (AU)

• Processo FAPESP: 13/16451-1 - Avaliação in vitro da contribuição de CCL2/MCP-1 e a importância de quimiocinas nos mecanismos de resistência e susceptibilidade à infecção por Leptospira sp.
• Beneficiário: Josefa Bezerra da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/20903-6 - Quimiocinas na leptospirose: caracterização do seu potencial antimicrobiano e sua interferência na expressão gênica de fatores de virulência em Leptospira sp.
• Beneficiário: Josefa Bezerra da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular