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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemokine expression profiles in liver and kidney of mice with different susceptibilities to leptospirosis

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Author(s):
Silva, Paloma L. D. [1] ; Nakajima, Erika [2] ; da Costa, Renata M. A. [3] ; Ho, Paulo Lee [4] ; Martins, Elizabeth A. L. [2] ; Carvalho, Eneas [1] ; da Silva, Josefa B. [1]
Total Authors: 7
Affiliation:
[1] Inst Butantan, Lab Bacteriol, Sao Paulo - Brazil
[2] Inst Butantan, Lab Biol Recombinantes, Sao Paulo - Brazil
[3] Global Antibiot Res & Dev Partnership GARDP, Drugs Neglected Dis Initiat DNDi, Chemin Louis Dunant 15, CH-1202 Geneva - Switzerland
[4] Inst Butantan, Div Bioind, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Microbial Pathogenesis; v. 149, DEC 2020.
Web of Science Citations: 1
Abstract

Leptospirosis is a global disease that affects humans and animals, impacting public health and the economy. The symptoms caused by Leptospira infection can vary from mild to severe, affecting liver, lungs, and kidneys. The host-pathogen interaction in leptospirosis is still poorly understood, but there is evidence for the role of the host immune response in the pathogenesis. Chemokines are a family of structurally-related low-molecular-mass proteins (8-14 kDa) that signal the recruitment of leukocytes. In this study the profile of 22 chemokines were evaluated in liver and kidney of three mice strains with different phenotypes of susceptibility to leptospirosis. We extended our previously reported observations showing that expression of chemokines with homeostatic function, activation and chemotaxis of leukocytes are essential to modulate and to induce resistance to leptospirosis. Our findings support that an early induction of CXC chemokines in resistant BALB/c mice can be associated with the control of the infection. The correlation of chemokine expression between liver and kidney observed in BALB/c suggests that a balance of chemokine induction in the organs may contribute to resistance to leptospirosis. (AU)

FAPESP's process: 13/16451-1 - In vitro evaluation of the contribution of CCL2/MCP-1 and the importance of chemokines in the mechanisms of resistance and susceptibility to infection with Leptospira sp.
Grantee:Josefa Bezerra da Silva
Support Opportunities: Regular Research Grants
FAPESP's process: 17/20903-6 - Chemokines in leptospirosis: characterization of its antimicrobial potential and interference in the gene expression of virulence factors in Leptospira sp.
Grantee:Josefa Bezerra da Silva
Support Opportunities: Regular Research Grants