Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): Absence of Changes in Maternal Reproductive Performance and Embryofetal Development In Vivo

Autor(es)

Camargo, Isabella Ferreira ^[1] ; Ajala Gaetano, Erika Leao ^[1] ; Pickler, Thaisa Borim ^[1] ; Gerenutti, Marli ^[1] ; Grotto, Denise ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sorocaba Uniso, Rodovia Raposo Tavares Km 92-5, BR-18023000 Sorocaba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Medicinal Mushrooms; v. 22, n. 8, p. 781-792, 2020.
• Citações Web of Science: 0

Resumo

The shiitake culinary-medicinal mushroom Lentinus edodes (=Lentinula edodes) has been used as a nutritional complement. This study evaluated, through reprotox tests, the consumption of L. edodes in pregnant rats, considering it as a functional food. Pregnant rats were daily exposed to L. edodes before implantation (LeB)-from 1 to 19 days of gestation, and after implantation (LeA)-from 9 to 19 days of gestation, compared with controls. On the 20th day of gestation, cesarean sections were performed. Blood was collected and hematological parameters (hemoglobin, hematocrit, white and red blood cells and platelets) were analyzed. Moreover, albumin, calcium, creatine kinase, alkaline phosphatase, transferases, creatinine, urea, triglycerides, cholesterol, lipase, glucose, and insulin were assessed in serum. Organs were collected and weighed, and the fetuses were analyzed morphologically by body measurements. The consumption of L. edodes reduced triglycerides levels and there were no changes in maternal weight, biochemical and hematological parameters, organ weight, and reproductive capacity. There were no morphological changes in the fetuses' body measurements, suggesting possible safety in ingestion of mushroom. Reprotox tests used to evaluate the daily consumption of L. edodes points out potentiality as a functional food, suggesting safety during the gestational period. (AU)

• Processo FAPESP: 15/24566-9 - Ensaios pré-clínicos com os cogumelos Agaricus blazei, Lentinula edodes e Ganoderma lucidum, visando à redução de danos maternos e fetais causados pelo diabetes gestacional.
• Beneficiário: Marli Gerenutti
• Modalidade de apoio: Auxílio à Pesquisa - Regular