Sensitive Voltammetric Detection of Chloroquine Drug by Applying a Boron-Doped Diamond Electrode

Autor(es)

Oliveira, Geiser Gabriel ^[1] ; Azzi, Deborah Christine ^[2] ; Silva, Tiago Almeida ^[3] ; de Oliveira, Paulo Roberto ^[4] ; Fatibello-Filho, Orlando ^[2] ; Janegitz, Bruno Campos ^[4]

Afiliação do(s) autor(es)

^[1] Fed Univ Tocantins, Chem Coll, BR-77402970 Gurupi, Tocantins - Brazil

^[2] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos, SP - Brazil

^[3] Fed Ctr Technol Educ Minas Gerais, Dept Met & Chem, BR-35180008 Timoteo, MG - Brazil

^[4] Univ Fed Sao Carlos, Dept Nat Sci Math & Educ, BR-13600970 Araras, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: C-JOURNAL OF CARBON RESEARCH; v. 6, n. 4 DEC 2020.
• Citações Web of Science: 0

Resumo

In this research, a boron-doped diamond (BDD) electrode has been explored to detect the chloroquine drug. The electrochemical performance of BDD electrode towards the irreversible anodic response of chloroquine was investigated by subjecting this electrode to the cathodic (-0.5 A cm(-2) by 180 s, generating a predominantly hydrogen-terminated surface) and anodic (+0.5 A cm(-2) by 30 s, oxygen-terminated surface) pretreatments. The cathodically pretreated BDD electrode ensured a better-defined anodic peak and higher current intensity. Thus, by applying the cathodically pretreated BDD electrode and square-wave voltammetry (SWV), the analytical curve was linear from 0.01 to 0.25 mu mol L-1 (correlation coefficient of 0.994), with sensitivity and limit of detection of 12.2 mu A L mu mol(-1) and 2.0 nmol(-1), respectively. This nanomolar limit of detection is the lowest recorded so far with modified and unmodified electrodes. (AU)

• Processo FAPESP: 20/01050-5 - Desenvolvimento e aplicação de sensores eletroquímicos e fotoeletroquímicos para a determinação de contaminantes emergentes em amostras de águas naturais
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