Sensitive Voltammetric Detection of Chloroquine Drug by Applying a Boron-Doped Diamond Electrode

Author(s)

Oliveira, Geiser Gabriel ^[1] ; Azzi, Deborah Christine ^[2] ; Silva, Tiago Almeida ^[3] ; de Oliveira, Paulo Roberto ^[4] ; Fatibello-Filho, Orlando ^[2] ; Janegitz, Bruno Campos ^[4]

Affiliation

^[1] Fed Univ Tocantins, Chem Coll, BR-77402970 Gurupi, Tocantins - Brazil

^[2] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos, SP - Brazil

^[3] Fed Ctr Technol Educ Minas Gerais, Dept Met & Chem, BR-35180008 Timoteo, MG - Brazil

^[4] Univ Fed Sao Carlos, Dept Nat Sci Math & Educ, BR-13600970 Araras, SP - Brazil

• Document type: Journal article
• Source: C-JOURNAL OF CARBON RESEARCH; v. 6, n. 4 DEC 2020.
• Web of Science Citations: 0

Abstract

In this research, a boron-doped diamond (BDD) electrode has been explored to detect the chloroquine drug. The electrochemical performance of BDD electrode towards the irreversible anodic response of chloroquine was investigated by subjecting this electrode to the cathodic (-0.5 A cm(-2) by 180 s, generating a predominantly hydrogen-terminated surface) and anodic (+0.5 A cm(-2) by 30 s, oxygen-terminated surface) pretreatments. The cathodically pretreated BDD electrode ensured a better-defined anodic peak and higher current intensity. Thus, by applying the cathodically pretreated BDD electrode and square-wave voltammetry (SWV), the analytical curve was linear from 0.01 to 0.25 mu mol L-1 (correlation coefficient of 0.994), with sensitivity and limit of detection of 12.2 mu A L mu mol(-1) and 2.0 nmol(-1), respectively. This nanomolar limit of detection is the lowest recorded so far with modified and unmodified electrodes. (AU)

• FAPESP's process: 20/01050-5 - Development and application of electrochemical and photoelectrochemical sensors for the determination of emerging contaminants in environmental samples
• Grantee: Orlando Fatibello Filho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use
• Grantee: Osmar Malaspina
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants