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Stabilization of vitamin C in emulsions of liquid crystalline structures

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Autor(es):
Carita, Amanda C. [1, 2] ; de Azevedo, Jacqueline Resende [2] ; Buri, Marcus Vinicius [3] ; Bolzinger, Marie-Alexandrine [2] ; Chevalier, Yves [1] ; Riske, Karin A. [4] ; Leonardi, Gislaine Ricci [5]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Translat Med, Sao Paulo - Brazil
[2] Univ Claude Bernard Lyon 1, Lab Automat Control Chem & Pharmaceut Engn LAGEPP, Villeurbanne - France
[3] Univ Fed Sao Paulo, Dept Biochem, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
[5] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: International Journal of Pharmaceutics; v. 592, JAN 5 2021.
Citações Web of Science: 0
Resumo

Emulsified systems are widely used for topical delivery with the aim of optimizing cutaneous absorption and offering a pleasant sensory. They also may provide a protection of the active molecule against oxidation and/or degradation. The oil phase of o/w emulsions may consist of liquid crystalline structures, especially lamellar structures which are similar to those found in the stratum corneum lipids. In the present work, o/w emulsions containing liquid crystals of mixed cetyl alcohol and Polysorbate 60 were developed for topical delivery of vitamin C, a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. In addition to the well-documented lipid supplementation of the stratum corneum, the liquid crystal emulsions provide a significant chemical stabilization of vitamin C against its degradation. Emulsions were characterized by X-ray diffraction, polarized optical microscopy, and transmission electron microscopy. The stability of vitamin C in the formulations was evaluated upon storage in different conditions of temperature. The emulsions contain a complex colloidal structure, consisting of lamellar liquid crystalline (L alpha) and crystalline lamellar gel (L beta) phases, that provide a very efficient protection of vitamin C against its degradation. (AU)

Processo FAPESP: 16/13368-4 - Sistemas nanoestruturados: de modelos biomiméticos de membranas a carreadores de bioativos
Beneficiário:Karin Do Amaral Riske
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/06973-4 - Desenvolvimento e caracterização de emulsões com cristais líquidos e emulsões Pickering para veiculação de ácido ascórbico
Beneficiário:Gislaine Ricci Leonardi
Linha de fomento: Auxílio à Pesquisa - Regular