Stabilization of vitamin C in emulsions of liquid crystalline structures

Autor(es)

Carita, Amanda C. ^{[1, 2]} ; de Azevedo, Jacqueline Resende ^[2] ; Buri, Marcus Vinicius ^[3] ; Bolzinger, Marie-Alexandrine ^[2] ; Chevalier, Yves ^[1] ; Riske, Karin A. ^[4] ; Leonardi, Gislaine Ricci ^[5]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Translat Med, Sao Paulo - Brazil

^[2] Univ Claude Bernard Lyon 1, Lab Automat Control Chem & Pharmaceut Engn LAGEPP, Villeurbanne - France

^[3] Univ Fed Sao Paulo, Dept Biochem, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil

^[5] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Pharmaceutics; v. 592, JAN 5 2021.
• Citações Web of Science: 0

Resumo

Emulsified systems are widely used for topical delivery with the aim of optimizing cutaneous absorption and offering a pleasant sensory. They also may provide a protection of the active molecule against oxidation and/or degradation. The oil phase of o/w emulsions may consist of liquid crystalline structures, especially lamellar structures which are similar to those found in the stratum corneum lipids. In the present work, o/w emulsions containing liquid crystals of mixed cetyl alcohol and Polysorbate 60 were developed for topical delivery of vitamin C, a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. In addition to the well-documented lipid supplementation of the stratum corneum, the liquid crystal emulsions provide a significant chemical stabilization of vitamin C against its degradation. Emulsions were characterized by X-ray diffraction, polarized optical microscopy, and transmission electron microscopy. The stability of vitamin C in the formulations was evaluated upon storage in different conditions of temperature. The emulsions contain a complex colloidal structure, consisting of lamellar liquid crystalline (L alpha) and crystalline lamellar gel (L beta) phases, that provide a very efficient protection of vitamin C against its degradation. (AU)

• Processo FAPESP: 16/13368-4 - Sistemas nanoestruturados: de modelos biomiméticos de membranas a carreadores de bioativos
• Beneficiário: Karin Do Amaral Riske
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/06973-4 - Desenvolvimento e caracterização de emulsões com cristais líquidos e emulsões Pickering para veiculação de ácido ascórbico
• Beneficiário: Gislaine Ricci Leonardi
• Modalidade de apoio: Auxílio à Pesquisa - Regular