Carita, Amanda C.
de Azevedo, Jacqueline Resende
Buri, Marcus Vinicius
Riske, Karin A.
Leonardi, Gislaine Ricci
Total Authors: 7
 Univ Fed Sao Paulo, Dept Translat Med, Sao Paulo - Brazil
 Univ Claude Bernard Lyon 1, Lab Automat Control Chem & Pharmaceut Engn LAGEPP, Villeurbanne - France
 Univ Fed Sao Paulo, Dept Biochem, Sao Paulo - Brazil
 Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
 Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas - Brazil
Total Affiliations: 5
International Journal of Pharmaceutics;
JAN 5 2021.
Web of Science Citations:
Emulsified systems are widely used for topical delivery with the aim of optimizing cutaneous absorption and offering a pleasant sensory. They also may provide a protection of the active molecule against oxidation and/or degradation. The oil phase of o/w emulsions may consist of liquid crystalline structures, especially lamellar structures which are similar to those found in the stratum corneum lipids. In the present work, o/w emulsions containing liquid crystals of mixed cetyl alcohol and Polysorbate 60 were developed for topical delivery of vitamin C, a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. In addition to the well-documented lipid supplementation of the stratum corneum, the liquid crystal emulsions provide a significant chemical stabilization of vitamin C against its degradation. Emulsions were characterized by X-ray diffraction, polarized optical microscopy, and transmission electron microscopy. The stability of vitamin C in the formulations was evaluated upon storage in different conditions of temperature. The emulsions contain a complex colloidal structure, consisting of lamellar liquid crystalline (L alpha) and crystalline lamellar gel (L beta) phases, that provide a very efficient protection of vitamin C against its degradation. (AU)