Stabilization of vitamin C in emulsions of liquid crystalline structures

Author(s)

Carita, Amanda C. ^{[1, 2]} ; de Azevedo, Jacqueline Resende ^[2] ; Buri, Marcus Vinicius ^[3] ; Bolzinger, Marie-Alexandrine ^[2] ; Chevalier, Yves ^[1] ; Riske, Karin A. ^[4] ; Leonardi, Gislaine Ricci ^[5]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Translat Med, Sao Paulo - Brazil

^[2] Univ Claude Bernard Lyon 1, Lab Automat Control Chem & Pharmaceut Engn LAGEPP, Villeurbanne - France

^[3] Univ Fed Sao Paulo, Dept Biochem, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil

^[5] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas - Brazil

• Document type: Journal article
• Source: International Journal of Pharmaceutics; v. 592, JAN 5 2021.
• Web of Science Citations: 0

Abstract

Emulsified systems are widely used for topical delivery with the aim of optimizing cutaneous absorption and offering a pleasant sensory. They also may provide a protection of the active molecule against oxidation and/or degradation. The oil phase of o/w emulsions may consist of liquid crystalline structures, especially lamellar structures which are similar to those found in the stratum corneum lipids. In the present work, o/w emulsions containing liquid crystals of mixed cetyl alcohol and Polysorbate 60 were developed for topical delivery of vitamin C, a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. In addition to the well-documented lipid supplementation of the stratum corneum, the liquid crystal emulsions provide a significant chemical stabilization of vitamin C against its degradation. Emulsions were characterized by X-ray diffraction, polarized optical microscopy, and transmission electron microscopy. The stability of vitamin C in the formulations was evaluated upon storage in different conditions of temperature. The emulsions contain a complex colloidal structure, consisting of lamellar liquid crystalline (L alpha) and crystalline lamellar gel (L beta) phases, that provide a very efficient protection of vitamin C against its degradation. (AU)

• FAPESP's process: 16/13368-4 - Nanostructured systems: from membrane biomimetic models to carriers of bioactives
• Grantee: Karin Do Amaral Riske
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 18/06973-4 - Development and characterization of Liquid Crystal Emulsions and Pickering emulsions for ascorbic acid
• Grantee: Gislaine Ricci Leonardi
• Support type: Regular Research Grants