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Nanostructured systems: from membrane biomimetic models to carriers of bioactives

Grant number: 16/13368-4
Support type:Research Projects - Thematic Grants
Duration: March 01, 2017 - February 28, 2023
Field of knowledge:Biological Sciences - Biophysics - Molecular Biophysics
Principal researcher:Karin Do Amaral Riske
Grantee:Karin Do Amaral Riske
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Julio Henrique Kravcuks Rozenfeld ; Katia Regina Perez ; Manoel de Arcisio Miranda Filho ; Omar Mertins
Associated grant(s):19/05713-1 - 12th EBSA and 10th ICBP-IUPAP Biophysical Congress, AR.EXT
18/20770-9 - 6th International Conference on Multifunctional, Hybrid and Nanomaterials, AR.EXT
17/05856-1 - 19th International Union of Pure and Applied Biophysics (IUPAB) and 11th European Biophysical Societies' Association (EBSA) Congress, AR.EXT
17/04604-9 - Multi-user equipment approved in grant 16/13368-4: spectrofluorimeter with polarizers, AP.EMU
17/04606-1 - Multi-user equipment approved in grant 16/13368-4: differential scanning calorimeter PEAQ-DSC, AP.EMU
Associated scholarship(s):22/10974-1 - Calorimetric study of the role of electrotatic interaction in the solubilization process of mimetic membranes by detergents, BP.IC
20/03998-6 - Effect of the interaction of antimicrobial peptides on the structuring of the lipid bilayer, BP.PD
20/08378-6 - Study of the interaction of the extract of Hibiscus Sabdariffa Linnaeus (hibisco) with membranes, BP.IC
+ associated scholarships 20/01417-6 - Structural characterization of DODAB vesicles containing C24:1 sulfatide, BP.IC
18/21727-0 - Cubosome drug carriers with bioconjugated functionalities and pH-responsive polymer shells, BE.PQ
17/15728-0 - Development and characterization of topical systems for ascorbic acid: comparative studies, BP.DR
17/16722-6 - pH responsive nanoparticles for optimization of oral delivery of antiparasite drugs in the treatment of ornamental fish, BP.MS
17/09367-5 - Study of the fusion mechanism of cationic fusogenic liposomes and their potential as carrier system, BP.DD - associated scholarships


Lipid and polymeric nanostructured systems are self-assembled systems with characteristic sizes in the nanometric scale. Among them, liposomes, nanoparticles, emulsions and continuous phases can be highlighted. Liposomes have been widely employed as mimetic models of biological membranes, due to their easy manipulation and for allowing precise control of the system components. Therefore, the fundamental aspects underlying a specific biological process involving the membrane can be studied in its essence in a simplified and controlled way. In addition, liposomal systems have been employed as bioactive molecules carriers. Nevertheless, depending on the drug and specific therapeutic target, these systems exhibit limitations in their application. Alternatively, polymeric nanoparticles and emulsions have been developed as biocompatible carriers with higher efficiency in preserving the bioactive compound stability in the biological milieu and to guarantee its controlled and site-directed delivery. This project envisages two main research topics: one with a focus on the membrane properties and their interaction with bioactive molecules with amphiphilic character, as peptides, detergents and neuromodulators, and a more applied one envisioning the use of nanostructured systems as carriers of compounds with pharmaceutical implication. The implementation of this project in a multidisciplinary environment of a medical school will allow the articulation of the proponent team and the consolidation of this emerging basic research area in membrane biophysics and carrier systems in the Department of Biophysics at EPM with potential application in biomedicine. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (21)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATHEWS, PATRICK D.; MERTINS, OMAR; MILANIN, TIAGO; ESPINOZA, LUIS L.; FLORES-GONZALES, ANAI P.; AUDEBERT, FABIENNE; MORANDINI, ANDRE C.. Molecular Phylogeny and taxonomy of a new Myxobolus species from the endangered ornamental fish, Otocinclus cocama endemic to Peru: A host-parasite coextinction approach. Acta Tropica, v. 210, . (16/13368-4, 15/18807-3, 18/20482-3, 15/23948-5, 15/21007-9)
MARTINS, DANUBIA BATISTA; PACCA, CAROLINA COLOMBELLI; DA SILVA, ANNIELLE MENDES BRITO; DE SOUZA, BIBIANA MONSON; DE ALMEIDA, MARGARETE TERESA GOTTARDO; PALMA, MARIO SERGIO; ARCISIO-MIRANDA, MANOEL; DOS SANTOS CABRERA, MARCIA PEREZ. Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation. Amino Acids, v. 52, n. 5, . (16/16212-5, 16/13368-4, 16/17951-6, 14/08372-7, 12/24259-0)
CARITA, AMANDA C.; DE AZEVEDO, JACQUELINE RESENDE; BURI, MARCUS VINICIUS; BOLZINGER, MARIE-ALEXANDRINE; CHEVALIER, YVES; RISKE, KARIN A.; LEONARDI, GISLAINE RICCI. Stabilization of vitamin C in emulsions of liquid crystalline structures. International Journal of Pharmaceutics, v. 592, . (16/13368-4, 18/06973-4)
MERTINS, OMAR; MATHEWS, PATRICK D.; ANGELOVA, ANGELINA. Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications. NANOMATERIALS, v. 10, n. 5, . (16/13368-4, 19/13147-6, 18/21727-0)
GARCIA, BIANCA B. M.; MERTINS, OMAR; DA SILVA, EMERSON R.; MATHEWS, PATRICK D.; HAN, SANG W.. Arginine-modified chitosan complexed with liposome systems for plasmid DNA delivery. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 193, . (16/13368-4, 15/23948-5, 15/20206-8)
DOMINGUES, TATIANA M.; PEREZ, KATIA R.; RISKE, KARIN A.. Revealing the Mode of Action of Halictine Antimicrobial Peptides: A Comprehensive Study with Model Membranes. Langmuir, v. 36, n. 19, p. 5145-5155, . (16/13368-4, 13/17762-0)
RIVADENEYRA, NORMA L. S.; MERTINS, OMAR; CUADROS, RUBEN C.; MALTA, JOSE C. O.; DE MATOS, LORENA V.; MATHEWS, PATRICK D.. Histopathology associated with infection by Procamallanus (Spirocamallanus) inopinatus (Nematoda) in farmed Brycon cephalus (Characiformes) from Peru: a potential fish health problem. AQUACULTURE INTERNATIONAL, . (16/13368-4, 18/20482-3, 15/23948-5)
COSTA PETRIN, THAIS H.; FADEL, VALMIR; MARTINS, DANUBIA B.; DIAS, SUSANA A.; CRUZ, ANA; SERGIO, LUCIANA MARCIANO; ARCISIO-MIRANDA, MANOEL; CASTANHO, MIGUEL A. R. B.; DOS SANTOS CABRERA, MARCIA P.. Synthesis and Characterization of Peptide-Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity. Biomacromolecules, v. 20, n. 7, p. 2743-2753, . (14/08372-7, 16/13368-4, 15/07548-7, 12/02065-0, 12/24259-0)
MATHEWS, PATRICK D.; MADRID, RAFAEL R. M.; MERTINS, OMAR; RIGONI, VERA L. S.; MORANDINI, ANDRE C.. A new Myxobolus (Cnidaria: Myxosporea) infecting the ornamental catfish Corydoras schwartzi from the Purus River in Brazil. EUROPEAN JOURNAL OF TAXONOMY, v. 620, p. 1-14, . (16/13368-4, 18/20482-3, 15/23948-5, 15/21007-9)
LIRA, RAFAEL B.; LEOMIL, FERNANDA S. C.; MELO, RENAN J.; RISKE, KARIN A.; DIMOVA, RUMIANA. To Close or to Collapse: The Role of Charges on Membrane Stability upon Pore Formation. ADVANCED SCIENCE, v. 8, n. 11, . (16/13368-4, 11/22171-6, 13/07246-5)
MARTINS, LETICIA S.; NOMURA, DANIELA A.; DUARTE, EVANDRO L.; RISKE, KARIN A.; TERESA LAMY, M.; ROZENFELD, JULIO H. K.. Structural characterization of cationic DODAB bilayers containing C24:1 beta-glucosylceramide. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1861, n. 3, p. 643-650, . (16/13368-4, 14/50983-3, 16/19077-1)
MATHEWS, PATRICK D.; PATTA, ANA C. M. FERNANDES; GONCALVES, JOAO V.; GAMA, GABRIELLA DOS SANTOS; GARCIA, IRENE TERESINHA SANTOS; MERTINS, OMAR. Targeted Drug Delivery and Treatment of Endoparasites with Biocompatible Particles of pH-Responsive Structure. Biomacromolecules, v. 19, n. 2, p. 499-510, . (16/13368-4, 17/16722-6, 15/23948-5)
ALMEIDA, MARCIO M.; PEREZ, KATIA R.; FAIG, ALLISON; UHRICH, KATHRYN E.; RISKE, KARIN A.. Location of the Positive Charges in Cationic Amphiphiles Modulates Their Mechanism of Action against Model Membranes. Langmuir, v. 35, n. 43, p. 14117-14123, . (16/13368-4)
MERTINS, OMAR; LOBO, SONJA ELLEN; MATHEWS, PATRICK D.; HAN, SANG WON. Interaction of pDNA with reverse phase chitosome. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 543, p. 76-82, . (16/13368-4, 15/20206-8, 15/23948-5)
ORTS, DIEGO J. B.; PEIGNEUR, STEVE; SILVA-GONCALVES, LAIZ COSTA; ARCISIO-MIRANDA, MANOEL; BICUDO, JOSE EDUARDO P. W.; TYTGAT, JAN. AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K+ Channels Activation. MARINE DRUGS, v. 16, n. 10, . (16/13368-4, 16/17951-6, 09/07128-7, 11/21031-6)
BRITO DA SILVA, ANNIELLE MENDES; SILVA-GONCALVES, LAIZ COSTA; OLIVEIRA, FERNANDO AUGUSTO; ARCISIO-MIRANDA, MANOEL. Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action. Molecular Neurobiology, v. 55, n. 7, p. 5490-5504, . (16/13368-4, 09/53840-0, 12/02065-0, 12/50336-2)
MADRID, RAFAEL R. M.; MATHEWS, PATRICK D.; PATTA, ANA C. M. F.; GONZALES-FLORES, ANAI P.; RAMIREZ, CARLOS A. B.; RIGONI, VERA L. S.; TAVARES-DIAS, MARCOS; MERTINS, OMAR. Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. HELIYON, v. 7, n. 1, . (16/13368-4, 18/20482-3, 15/23948-5, 17/16722-6)
FERNANDES PATTA, ANA C. M.; MATHEWS, PATRICK D.; MADRID, RAFAEL R. M.; RIGONI, VERA L. S.; SILVA, EMERSON R.; MERTINS, OMAR. Polyionic complexes of chitosan-N-arginine with alginate as pH responsive and mucoadhesive particles for oral drug delivery applications. International Journal of Biological Macromolecules, v. 148, p. 550-564, . (16/13368-4, 17/16722-6, 18/20482-3, 15/23948-5, 16/24409-3)
LIRA, RAFAEL B.; ROBINSON, TOM; DIMOVA, RUMIANA; RISKE, KARIN A.. Highly Efficient Protein-free Membrane Fusion: A Giant Vesicle Study. BIOPHYSICAL JOURNAL, v. 116, n. 1, p. 79-91, . (16/13368-4, 11/22171-6, 13/07246-5)
MARTINS, LETICIA S.; DUARTE, EVANDRO L.; LAMY, M. TERESA; ROZENFELD, JULIO H. K.. Supramolecular organization of a-galactosylceramide in pure dispersions and in cationic DODAB bilayers. Chemistry and Physics of Lipids, v. 232, . (14/50983-3, 16/19077-1, 16/13368-4)

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