| Grant number: |
16/09633-4
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| Support type: | Scholarships in Brazil - Post-Doctorate |
| Effective date (Start): |
September 01, 2016
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| Effective date (End): |
September 30, 2020
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| Field of knowledge: | Physical Sciences and Mathematics
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Physics
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Condensed Matter Physics |
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| Principal Investigator: | Carlos José Leopoldo Constantino |
| Grantee: | Wallance Moreira Pazin |
|
| Home Institution: |
Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
|
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| Associated research grant: | 13/14262-7 - Nanostructured films from biologically-relevant materials,
AP.TEM
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| Associated scholarship(s): | 17/23426-4 - Insights on the interaction of Artepillin C with tumor cell membranes: an advanced fluorescence microscopy study,
BE.EP.PD
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Abstract
Green propolis is a mixture of bees wax and resinous compounds processed by the species Apis mellifera, with a broad spectrum of pharmacological properties. Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid), is the major identified compound of green propolis, constituted by two prenylated groups bound to a phenyl group. The antitumor effects of this molecule have been the focus of several studies, but so far there is no evidence for its interaction with amphiphilic aggregates that mimic membranes of tumor cells, which may be the initial step essential to elicit the biological action of Artepillin C, mainly due its amphiphilic propertie, probably promoting dynamic and structural alterations in the membranes. These features motivate us to investigate the mechanism of action of the compound Artepillin C in membranes of tumor cells and their models, investigating particularities as lipid composition, lateral organization and the influence of microdomains in their structures, as such as the concentration of the bioactive compound for the action and the influence of pH and ionic strength in the system. The presented project is part of the thematic "Nanostructured films from biologically-relevant materials", FAPESP process 2013/14262-7, will be developed by means of methodologies based on fluorescence microscopy, using giant unilamellar vesicles (GUVs), Langmuir monolayers and Langmuir-Blodgett (LB) films as membrane biomimetic systems.
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Scientific publications
(12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAZIN, WALLANCE M.;
FURINI, LEONARDO N.;
SOLOVYEVA, VITA;
LEMMA, TIBEBE;
RUBIRA, RAFAEL J. G.;
JORGENSEN, BJARKE;
CONSTANTINO, CARLOS J. L.;
BREWER, JONATHAN R.
Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C.
Applied Spectroscopy,
v. 74,
n. 7
APR 2020.
Web of Science Citations: 0.
DE CAMPOS, ISABELE AP. S.;
DOS SANTOS, EDJANE R.;
SELLANI, TARCISO ALMEIDA;
HERBOZO, CAROLINA C. A.;
RODRIGUES, ELAINE G.;
ROVEDA, ANTONIO C.;
PAZIN, WALLANCE M.;
ITO, AMANDO S.;
SANTANA, VINICIUS T.;
NASCIMENTO, OTACIRO R.;
CARLOS, ROSE M.
Influence of the Medium on the Photochemical and Photophysical Properties of [Ru(phen)(2)(pPDIp)](2+).
CHEMPHOTOCHEM,
v. 2,
n. 8,
p. 757-764,
AUG 2018.
Web of Science Citations: 0.
PAZIN, WALLANCE MOREIRA;
MONACO, LUCIANA DA MATA;
EGEA SOARES, ADEMILSON ESPENCER;
MIGUEL, FELIPE GALETI;
BERRETTA, ANDRESA APARECIDA;
ITO, AMANDO SIUITI.
Antioxidant activities of three stingless bee propolis and green propolis types.
JOURNAL OF APICULTURAL RESEARCH,
v. 56,
n. 1,
p. 40-49,
2017.
Web of Science Citations: 7.