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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of the Medium on the Photochemical and Photophysical Properties of [Ru(phen)(2)(pPDIp)](2+)

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de Campos, Isabele Ap. S. [1] ; dos Santos, Edjane R. [1] ; Sellani, Tarciso Almeida [2] ; Herbozo, Carolina C. A. [2] ; Rodrigues, Elaine G. [2] ; Roveda, Antonio C. [3] ; Pazin, Wallance M. [4] ; Ito, Amando S. [5] ; Santana, Vinicius T. [6] ; Nascimento, Otaciro R. [6] ; Carlos, Rose M. [1]
Total Authors: 11
[1] Univ Fed Sao Carlos UFSCar, Dept Quim, Rodovia Washington Luis S-N, Sao Carlos, SP - Brazil
[2] Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, R Botucatu 862, 88 AndarVila Clementino, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Quim Sao Carlos, Av Trab Sao Carlense, 400Parque Arnold Schimidt, Sao Carlos, SP - Brazil
[4] Univ Estadual Paulista Julio de Mesquita Filho UN, Dept Fis, Rua Roberto Simonsen 305, Presidente Prudente, SP - Brazil
[5] Univ Sao Paulo, Dept Fis FFLRP USP, Av Bandeirantes 3900, Ribeirao Preto, SP - Brazil
[6] Univ Sao Paulo, Inst Fis Sao Carlos, Av Trab Sao Carlense, 400 Parque Arnold Schimidt, Sao Carlos, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: CHEMPHOTOCHEM; v. 2, n. 8, p. 757-764, AUG 2018.
Web of Science Citations: 0

This study reports the influence of the medium on the aggregation processes of the complex {[}Ru(phen)(2)(pPDIp)](2+)(phen=1,10-phenanthroline; pPDIp=a bis-phenanthroline-substituted perylene diimide)and its consequences for the photochemical and photophysical properties of the system. Photolysis leads, initially, to emission of both chromophores: Triplet metal-to-ligand charge transfer ((MLCT)-M-3{*}; Ru, dphen, {*}) and singlet intraligand charge transfer ((ILCT)-I-1{*}; pPDIp, {*}). However, the medium induces increased - intermolecular interactions that lead to the generation of a pPDIp(.-)moietyin DMSO, pPDIp(.-) (518nm) and pPDIp(.-) and pPDIp(2-)(420nm) in the cell culture medium RPMI, and (3{*})pPDIp in buffer (pH7.4) and starch films. The complex activates singlet oxygen in buffer solution without oxygen bubbling and under green light irradiation (dose=0.41J/cm(2); {[}O-1(2)]=0.03-0.47molL(-1) for {[}Ru(phen)(2)(pPDIp)](2+)=10-150molL(-1)). No cytotoxic effects on B16F10-Nex2 murine melanoma cell viability were observed up to a concentration of 10molL(-1) of complex. However, under green LED illumination (dose=0.41J/cm(2)) the complex exhibits a strong photocytotoxic effect, displaying IC50=1.2molL(-1). (AU)

FAPESP's process: 17/00839-1 - Analysis of the structure-toxicity relationship of b-amyloid peptides and neuroprotective effect of luminescent Ru (II) complexes
Grantee:Rose Maria Carlos
Support type: Regular Research Grants
FAPESP's process: 16/09633-4 - Mechanism of action of the bioactive compound Artepillin C in membrane biomimetic systems and cytoplasmic membrane of tumor cells
Grantee:Wallance Moreira Pazin
Support type: Scholarships in Brazil - Post-Doctorate