| Texto completo | |
| Autor(es): |
Número total de Autores: 2
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Surg, Div Urol, Human Reprod Sect, Rua Embau 31, BR-04039060 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH; v. 1868, n. 2 FEB 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Background: Different animal species have different characteristics regarding the transmission of mitochondrial DNA. While some species have biparental mitochondrial inheritance, others have developed pathways to remove paternal mtDNA. These pathways guarantee the uniparental mitochondrial inheritance, so far well known in mammals, avoiding heteroplasmy, which may have the potential to cause certain mitochondrial diseases in the offspring. Scope of review: This review aims to address the main mechanisms that involve mitochondrial degradation in different animal species, as well as to describe what is present in the literature on the mechanisms involved in mitochondrial inheritance. Major conclusions: Two theories are proposed to explain the uniparental inheritance of mtDNA: (i) active degradation, where mechanisms for paternal mitochondrial DNA elimination involve mitochondrial degradation pathway by autophagy and, in some species, may also involve the endocytic degradation pathway; and (ii) passive dilution, where the paternal mitochondria are diluted in the cells of the embryo according to cell division, until becoming undetectable. General significance: This work brings a wide review of the already published evidence on mitochondrial inheritance in the animal kingdom and the possible mechanisms to mtDNA transmission already described in literature. (AU) | |
| Processo FAPESP: | 17/14346-7 - Lesão medular e infertilidade masculina: efeito do tratamento com probenecida sobre a toxicidade seminal de origem prostática. |
| Beneficiário: | Mariana Camargo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/25907-2 - Análise da mitofagia espermática após fertilização in vitro |
| Beneficiário: | Karla Pacheco de Melo |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |