ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study

Autor(es)

Oliveira Monteiro, Maria Patricia A. ^[1] ; Salheb Oliveira, Danielle S. M. ^[1] ; Manzine, Patricia R. ^[1] ; Crispim Nascimento, Carla M. ^[1] ; dos Santos Orlandi, Ariene A. ^[2] ; de Oliveira Gomes, Grace A. ^[1] ; Orlandi, Fabiana dos Santos ^[1] ; Zazzetta, Marisa S. ^[1] ; Pott-Junior, Henrique ^[3] ; Cominetti, Marcia R. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Carlos UFSCar, Dept Gerontol, Rodovia Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Fed Univ Sao Carlos UFSCar, Dept Nursing, Sao Carlos - Brazil

^[3] Fed Univ Sao Carlos UFSCar, Dept Med, Sao Carlos - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ALZHEIMERS RESEARCH & THERAPY; v. 13, n. 1 JAN 8 2021.
• Citações Web of Science: 0

Resumo

BackgroundBlood-based biomarkers for Alzheimer's disease (AD) are highly needed in clinic practice. So far, the gold standards for AD diagnosis are brain neuroimaging and beta-amyloid peptide, total tau, and phosphorylated tau in cerebrospinal fluid (CSF); however, they are not attractive for large-scale screening. Blood-based biomarkers allow an initial large-scale screening of patients under suspicion that could later be tested for the already established CSF biomarkers. To this regard, in this study, we evaluated whether plasma ADAM10 levels would be predictors of declines in cognition in community-dwelling older adults after a 3-year period follow-up.MethodsThis was a 3-year longitudinal cohort study that included 219 community-dwelling older adults. Sociodemographic, clinical, lifestyle, depressive symptoms (GDS), and cognitive data (Mini-Mental State Examination, MMSE; Clock Drawing test, CDT) were gathered. The measurement of ADAM10 plasma levels was performed using a sandwich ELISA kit. Bivariate comparisons between groups were performed using Wilcoxon-Mann-Whitney for continuous data and Pearson's chi-square tests with Yates continuity correction for categorical data. Longitudinal analyzes of changes in the MMSE scores were performed using linear mixed-effects modeling.ResultsBaseline MMSE scores and ADAM10 levels were significantly associated with MMSE scores on the follow-up assessment. When analyzing the interaction with time, normal MMSE scores and the ADAM10 plasma levels at baseline presented a significant and independent negative association with MMSE score values on the follow-up assessment. The analyses also showed that the predictive effect of ADAM10 plasma levels on decreasing MMSE scores on follow-up seems to be more pronounced in participants with normal MMSE, when compared with those with altered MMSE scores at baseline.ConclusionsConsidering that ADAM10 increase in plasma is detected as soon as in mild cognitive impairment (MCI) patients, the results presented here may support the complementary clinical use of this biomarker, in addition to the classical AD biomarkers. Taken together, these results provide the first direct evidence that changes in ADAM10 plasma levels are predictors of cognitive worsening in older adults. Moreover, this work can shed light on the study of blood biomarkers for AD and contribute to the advancement of the area. (AU)

• Processo FAPESP: 16/15235-1 - Ferramenta de monitoramento de níveis de fragilidade em idosos atendidos na atenção básica de saúde: avaliação da sua efetividade e eficiência
• Beneficiário: Marisa Silvana Zazzetta
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS
• Processo FAPESP: 19/02648-4 - Papel de proteínas da via de sinalização da insulina e sua relação com a secretase ADAM10 na Doença de Alzheimer
• Beneficiário: Márcia Regina Cominetti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50104-0 - Ferramenta para monitoramento de níveis de fragilidade e fatores associados em idosos atendidos pelo Núcleo de Apoio à Saúde da Família (NASF) no Município de São Carlos
• Beneficiário: Marisa Silvana Zazzetta
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS