Breath Biopsy and Discovery of Exclusive Volatile Organic Compounds for Diagnosis of Infectious Diseases

Autor(es)

Belizario, Jose E. ^[1] ; Faintuch, Joel ^[2] ; Malpartida, Miguel Garay ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Arts Sci & Humanities EACH, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 10, JAN 7 2021.
• Citações Web of Science: 0

Resumo

Exhaled breath contains thousand metabolites and volatile organic compounds (VOCs) that originated from both respiratory tract and internal organ systems and their microbiomes. Commensal and pathogenic bacteria and virus of microbiomes are capable of producing VOCs of different chemical classes, and some of them may serve as biomarkers for installation and progression of various common human diseases. Here we describe qualitative and quantitative methods for measuring VOC fingerprints generated by cellular and microbial metabolic and pathologic pathways. We describe different chemical classes of VOCs and their role in the host cell-microbial interactions and their impact on infection disease pathology. We also update on recent progress on VOC signatures emitted by isolated bacterial species and microbiomes, and VOCs identified in exhaled breath of patients with respiratory tract and gastrointestinal diseases, and inflammatory syndromes, including the acute respiratory distress syndrome and sepsis. The VOC curated databases and instrumentations have been developed through statistically robust breathomic research in large patient populations. Scientists have now the opportunity to find potential biomarkers for both triage and diagnosis of particular human disease. (AU)

• Processo FAPESP: 18/24922-8 - Disbiose e imunometabolismo do microbioma intestinal: novas fronteiras para o tratamento de doenças metabólicas
• Beneficiário: Humberto Miguel Garay Malpartida
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo
• Processo FAPESP: 07/04513-1 - Papel da nova citocina PANDER na indução de apoptose ou proliferação celular em linhagens tumorais de próstata e de mama
• Beneficiário: Humberto Miguel Garay Malpartida
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/18647-6 - Human microbiomes and their roles in dysbiosis, common diseases and novel therapeutic approaches
• Beneficiário: José Ernesto Belizario
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo