| Texto completo | |
| Autor(es): |
Lima, Maria L. S. O.
[1, 2]
;
Braga, Carolyne B.
[1]
;
Becher, Tiago B.
[1]
;
Odriozola-Gimeno, Mikel
[3, 4]
;
Torrent-Sucarrat, Miquel
[3, 4, 5]
;
Rivilla, Ivan
[3, 4]
;
Cossio, Fernando P.
[3, 4]
;
Marsaioli, Anita J.
[1]
;
Ornelas, Catia
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Campinas Unicamp, Inst Chem, BR-13083861 Campinas, SP - Brazil
[2] Inst Fed Bahia IFBA, Campus Juazeiro, BR-48918900 Juazeiro, BA - Brazil
[3] Univ Pais Vasco Euskal Herriko Unibertsitatea UPV, Ctr Innovac Quim Avanzada ORFEO CINQA, Dept Organ Chem 1, P Manuel Lardizabal 3, Donostia San Sebastian 20018 - Spain
[4] Donostia Int Phys Ctr DIPC, P Manuel Lardizabal 3, Donostia San Sebastian 20018 - Spain
[5] Ikerbasque, Basque Fdn Sci, Ma Diaz Haro 3, Bilbao 48013 - Spain
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRY-A EUROPEAN JOURNAL; v. 27, n. 20 JAN 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Photodynamic therapy has been used to treat a variety of diseases, however, there is continuing search for new biocompatible photosensitizers. Herein, we demonstrate for the first time that imidazo{[}1,2-a]pyrimidine compounds are able to generate singlet oxygen species and can act as photosensitizers in the intracellular environment. Our results show that this class of compounds absorb and emit in the 400-500 nm region, present low cytotoxicity in the dark, are efficiently uptaken by cells, are fluorescent in intracellular medium, and generate singlet oxygen upon irradiation, killing cancer cells within 2 h at low concentration (2.0 mu m). The imidazo{[}1,2-a]pyrimidine compounds are a potential new tool for phototheranostics, because they can be simultaneously used for fluorescence imaging and photodynamic therapy. (AU) | |
| Processo FAPESP: | 17/06146-8 - Desenvolvimento de nanocarregadores baseados em dendrímeros e nanopartículas poliméricas para a vetorização seletiva da goniotalamina, piplartina e monastrol |
| Beneficiário: | Carolyne Brustolin Braga |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/02093-0 - Desenvolvimento de novos nanomateriais para aplicações em nanomedicina |
| Beneficiário: | Cátia Cristina Capêlo Ornelas Megiatto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |