TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization

Autor(es):Mostrar menos -

Costa, I, A. ; Gemini-Piperni, S. ^{[1, 2]} ; Alves, A. C. ^[3] ; Costa, N. A. ^{[1, 4]} ; Checca, N. R. ^[5] ; Leite, P. E. ^{[6, 7]} ; Rocha, L. A. ^{[1, 8]} ; Pinto, A. M. P. ^{[3, 9]} ; Toptan, F. ^{[3, 1]} ; Rossi, A. L. ^[5] ; Ribeiro, A. R. ^{[1, 2, 6, 10, 11]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Sao Paulo State Univ, Inst Biomat Tribocorros & Nanomed, Brazilian Branch, IBTN Br, Bauru, SP - Brazil

^[2] Univ Grande Rio, Postgrad Program Translat Biomed, Duque De Caxias, RJ - Brazil

^[3] Costa, A., I, Univ Minho, CMEMS UMinho Ctr MicroElectroMech Syst, Guimaraes - Portugal

^[4] Sao Paulo State Univ, Postgrad Program Mat Sci & Technol, Bauru, SP - Brazil

^[5] CBPF Brazilian Ctr Res Phys, Rio De Janeiro - Brazil

^[6] Natl Inst Metrol Qual & Technol, Postgrad Program Biotechnol, Xerem, RJ - Brazil

^[7] Natl Inst Metrol Qual & Technol, Directory Life Sci Appl Metrol, Xerem, RJ - Brazil

^[8] Sao Paulo State Univ, Fac Sci, Dept Phys, Bauru, SP - Brazil

^[9] Univ Minho, DEM Dept Mech Engn, Guimaraes - Portugal

^[10] Univ Minho, 3Bs Res Grp, Res Inst Biomat Biodegradables & Biomimet, Guimaraes - Portugal

^[11] Univ Minho, European Inst Excellence Tissue Engn & Regenerat, Guimaraes - Portugal

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 120, JAN 2021.
• Citações Web of Science: 0

Resumo

One of the main problems that remain in the implant industry is poor osseointegration due to bioinertness of implants. In order to promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO2 porous layer produced by micro-arc oxidation. Ca and P as bioactive elements are already well reported in the literature, however, the knowledge of the effect of Sr is still limited. In the present work, the effect of various amounts of Sr was evaluated and the morphology, chemical composition and crystal structure of the oxide layer were investigated. Furthermore, in vitro studies were carried out using human osteoblast-like cells. The oxide layer formed showed a triplex structure, where higher incorporation of Sr increased Ca/P ratio, amount of rutile and promoted the formation of SrTiO3 compound. Biological tests revealed that lower concentrations of Sr did not compromise initial cell adhesion neither viability and interestingly improved mineralization. However, higher concentration of Sr (and consequent higher amount of rutile) showed to induce collagen secretion but with compromised mineralization, possibly due to a delayed mineralization process or induced precipitation of deficient hydroxyapatite. Ca-P-TiO2 porous layer with less concentration of Sr seems to be an ideal candidate for bone implants. (AU)

• Processo FAPESP: 17/24300-4 - Um novo conceito para produzir materiais bio-funcionalizados com gradiente de propriedades para implantes ortopédicos
• Beneficiário: Luís Augusto Sousa Marques da Rocha
• Modalidade de apoio: Auxílio à Pesquisa - Regular