Polymorphism in the catalytic subunit of the PI3K gamma gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy

Autor(es)

Silva, Maria Claudia ^[1] ; Medina, Tiago da Silva ^{[2, 1]} ; Fuzo, Carlos Alessandro ^[3] ; Dias, Fabricio Cesar ^[4] ; Freitas-Castro, Felipe ^[5] ; Fukutani, Kiyoshi Ferreira ^[1] ; Donadi, Eduardo Antonio ^[4] ; Cunha-Neto, Edecio ^[6] ; Cunha, Thiago Mattar ^[7] ; Silva, Joao Santana ^{[1, 8]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch, Dept Biochem & Immunol Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[2] AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Med, Div Clin Immunol, Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cell & Mol Biol, Ribeirao Preto - Brazil

^[6] Univ Sao Paulo, Sch Med, Heart Inst, Lab Immunol, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP - Brazil

^[8] Univ Sao Paulo, Ribeirao Preto Med Sch, Fiocruz Biinst Translat Med Plataform, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INFECTION GENETICS AND EVOLUTION; v. 88, MAR 2021.
• Citações Web of Science: 0

Resumo

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. During the chronic phase of disease, while most infected people do not present symptoms, characterizing the asymptomatic form, some patients develop the cardiac form or chronic chagasic cardiomyopathy, which is considered the most severe manifestation of this disease. Considering that the activation of the PI3K gamma signaling pathway is essential for an efficient immune response against T. cruzi infection, we evaluated the PIK3CG C > T (rs1129293) polymorphism in exon 3 of this gene, which encodes the catalytic subunit of PI3K gamma. The PIK3CG CT and TT genotypes were found to be associated with an increased risk of developing the cardiac form of the disease rather than the asymptomatic or digestive forms. In conclusion, the presence of the T allele at single or double doses may differentiate the cardiac from other clinical manifestations of Chagas disease. This finding should help in further studies to evaluate the mechanisms underlying the differential association of PIK3CG in Chagas disease. (AU)

• Processo FAPESP: 18/20130-0 - Função, mecanismos de ativação e regulação das vias da PI3K delta e PI3K gama no controle da infecção pelo Trypanosoma cruzi.
• Beneficiário: Maria Cláudia da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias
• Beneficiário: Fernando de Queiroz Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs