| Texto completo | |
| Autor(es): |
Simoes, Estefania
[1]
;
Correia-Lima, Joanna
[1]
;
Calfat, Elie Leal de Barros
[2]
;
Otani, Thais Zelia dos Santos
[2]
;
Vasques, Daniel Augusto Correa
[2]
;
Otani, Victor Henrique Oyamada
[2]
;
Bertolazzi, Pamela
[2]
;
Kochi, Cristiane
[3]
;
Seelaender, Marilia
[4, 1, 5]
;
Uchida, Ricardo Riyoiti
[2]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Canc Metab Res Grp, Sao Paulo - Brazil
[2] Santa Casa Sao Paulo Sch Med Sci, Mental Hlth Dept, Sao Paulo - Brazil
[3] Santa Casa Sao Paulo Sch Med Sci, Physiol Dept, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil
[5] Hosp Clin Univ Sao Paulo, Lab Invent Med 26, Sao Paulo - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN NUTRITION; v. 7, FEB 12 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Objective: Childhood obesity is a growing concern as the World Health Organization (WHO) states that similar to 10% of adolescents worldwide are overweight or obese. This condition is the reflex of energy imbalance between the calories consumed and those expended. Sex-related responses associated with dyslipidemia, hormonal alterations, and neuro-humoral disruptions in childhood obesity are the focus of the present investigation. Methods: Ninety-two Brazilian adolescents were enrolled and divided between obese and eutrophic groups. Obesity was assessed using body mass index Z-score according to age and weight. Anthropometrical analyses, blood pressure, blood lipids, metabolism-regulating hormones, and neuropeptides were carried out. Results: Systolic blood pressure was higher in female and male patients with obesity. Obese females presented alterations in lipid profile and an augment of cardiovascular disease prediction ratios TC/HDL, TG/HDL, LDL/HDL, and VLDL/HDL. The levels of leptin, GIP, and neuropeptide showed sex-dimorphism in obesity. The obese adolescents presented increased levels of circulating insulin, c-peptide, amylin, glucagon, and GLP-1. Correlation analysis showed significant linearity between body mass index, blood pressure, lipids, lipoproteins, hormones, and neuropeptides content. Conclusions: Our data support an existing link associating hypertension, dyslipidemia, and neuro-hormonal imbalance in childhood obesity. We also described a sex-dependent pattern in childhood obesity-associated dyslipidemia and blood pressure in female patients with obesity solely. (AU) | |
| Processo FAPESP: | 12/50079-0 - Inflamação sistêmica em pacientes com caquexia associada ao câncer: mecanismos e estratégias terapêuticas, uma abordagem em medicina translacional |
| Beneficiário: | Marilia Cerqueira Leite Seelaender |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 12/21677-6 - Avaliação de anatomia cerebral, mediadores inflamatórios e hormônios reguladores do apetite de pacientes pediátricos obesos: um estudo sobre a neurobiologia da obesidade |
| Beneficiário: | Ricardo Riyoiti Uchida |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |