Analysis of the Functional Aspects of Sperm and Testicular Oxidative Stress in Individuals Undergoing Metabolic Surgery

Autor(es)

Fariello, Roberta Maria ^[1] ; de Carvalho, Renata Cristina ^[1] ; Spaine, Deborah M. ^[1] ; Andretta, Rhayza R. ^[1] ; Caetano, Jr., Elesiario M. ^{[2, 3]} ; Sa, Gustavo P. D. ^[3] ; Cedenho, Agnaldo P. ^[1] ; Fraietta, Renato ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo Fed Univ, Div Urol, Dept Surg, Human Reprod Sect, R Napoleao de Barros 715, 2 Floor, BR-04024002 Sao Paulo, SP - Brazil

^[2] Sao Paulo Fed Univ, Dept Surg, Div Surg Gastroenterol, R Napoleao de Barros 715, 2 Floor Vila Clementino, BR-04024002 Sao Paulo, SP - Brazil

^[3] Gastros Clin, R Borges Lagoa 1070, BR-04038002 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: OBESITY SURGERY; v. 31, n. 7 MAR 2021.
• Citações Web of Science: 0

Resumo

Purpose Metabolic surgery is a recommended treatment for obese patients that results in BMI reduction; however, the observed impact of this therapy on male fertility is inconsistent. This research aimed to study the effects of BMI changes after metabolic surgery on seminal analysis, sex hormonal profile, sperm functional integrity, and the seminal plasma lipid peroxidation levels. Materials and Methods A prospective study was performed in 15 patients for whom metabolic surgery was recommended. The patients were evaluated by the techniques proposed in this study before and after the surgical procedure for 12 months. In each analysis, the male sex hormonal profile, semen analysis, sperm functional integrity, and seminal lipid peroxidation levels were assessed. Results The surgery resulted in BMI reduction and improvement in seminal characteristics and male sex hormone profile. The semen analysis showed increases in volume, sperm progressive motility, and in sperm morphology and a decrease in immotile sperms. Sperm mitochondrial activity and sperm DNA integrity were improved, and the levels of seminal lipid peroxidation were decreased. The hormonal profile showed lower levels of estradiol and highest levels of luteinizing hormone (LH), sex hormone-binding globulin (SHBG), and testosterone. Conclusion BMI changes resulting from this treatment and its metabolic consequences can be associated with changes in the male fertile potential, leading to an improvement in the seminal quality, male sex hormone profile, sperm functional aspects, and levels of seminal lipid peroxidation, thus decreasing the testicular oxidative stress. (AU)

• Processo FAPESP: 12/17986-3 - Análise dos aspectos funcionais dos espermatozóides e do estresse oxidativo testicular de indivíduos submetidos à cirurgia metabólica
• Beneficiário: Roberta Maria Fariello
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado