Probing axial metal distribution on biopolymer-based layer-by-layer films for antimicrobial use

Autor(es)

Taketa, Thiago B. ^[1] ; Bataglioli, Rogerio A. ^[1] ; Rocha Neto, Joao Batista M. ^[1] ; Beppu, Marisa M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Chem Engn, 500 Albert Einstein Av, BR-13083852 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 199, MAR 2021.
• Citações Web of Science: 0

Resumo

This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications. Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C-60(+) cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy. Despite the use of the layer-by-layer approach for film assembly, these PEM films present a nonstratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction. Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity. The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior. (AU)

• Processo FAPESP: 16/10193-9 - Desenvolvimento de mecanismos de ativação e controle da liberação de fármacos em mochilas celulares para uso em terapias antitumorais
• Beneficiário: Rogério Aparecido Bataglioli
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/20560-4 - Desenvolvimento de materiais bioativos a base de proteínas e polímeros naturais visando aplicações de interesse biomédico.
• Beneficiário: Marisa Masumi Beppu
• Modalidade de apoio: Auxílio à Pesquisa - Regular