Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic

Autor(es):Mostrar menos -

Buss, Lewis F. ^{[1, 2]} ; Prete Jr, Carlos A. ; Abrahim, Claudia M. M. ^[3] ; Mendrone Jr, Alfredo ; Salomon, Tassila ^{[4, 5]} ; de Almeida-Neto, Cesar ^{[6, 7]} ; Franca, Rafael F. O. ^[8] ; Belotti, Maria C. ^[9] ; Carvalho, Maria P. S. S. ^[3] ; Costa, Allyson G. ^[3] ; Crispim, Myuki A. E. ^[3] ; Ferreira, Suzete C. ^{[6, 7]} ; Fraiji, Nelson A. ^[3] ; Gurzenda, Susie ^[10] ; Whittaker, Charles ^[11] ; Kamaura, Leonardo T. ^[12] ; Takecian, Pedro L. ^[12] ; Peixoto, Pedro da Silva ^[12] ; Oikawa, Marcio K. ^[13] ; Nishiya, Anna S. ^{[6, 7]} ; Rocha, Vanderson ^{[6, 7]} ; Salles, Nanci A. ^[6] ; de Souza Santos, Andreza Aruska ^[14] ; da Silva, Martirene A. ^[3] ; Custer, Brian ^{[15, 16]} ; Parag, V, Kris ; Barral-Netto, Manoel ^[17] ; Kraemer, Moritz U. G. ^[18] ; Pereira, Rafael H. M. ^[19] ; Pybus, Oliver G. ^[18] ; Busch, Michael P. ^{[15, 16]} ; Castro, Marcia C. ^[10] ; Dye, Christopher ^[18] ; Nascimento, Vitor H. ^[9] ; Faria, Nuno R. ^{[1, 18, 2, 20]} ; Sabino, Ester C. ^{[1, 2]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Sao Paulo, Fac Med, Dept Molestias Infecciosas & Parasitarias, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Inst Med Trop, Sao Paulo - Brazil

^[3] Fundacao Hosp Hematol & Hemoterapia Amazonas, Manaus, Amazonas - Brazil

^[4] Fundacao Hemominas Fundacao Ctr Hematol & Hemoter, Belo Horizonte, MG - Brazil

^[5] Fac Ciencias Med Minas Gerais, Belo Horizonte, MG - Brazil

^[6] Mendrone Jr, Jr., Alfredo, Fundacao Pro Sangue Hemoctr Sao Paulo, Sao Paulo - Brazil

^[7] Mendrone Jr, Jr., Alfredo, Univ Sao Paulo, Hosp Clin HCFMUSP, Dept Hematol, Fac Med, Lab Invest Med Patogenese & Terapia Dirigida Onco, Sao Paulo - Brazil

^[8] Fundacao Oswaldo Cruz, Inst Aggeu Magalhaes, Dept Virol & Expt Therapy, Recife, PE - Brazil

^[9] Prete Jr, Jr., Carlos A., Escola Politecn Univ Sao Paulo, Dept Engn Sistemas Eletron, Sao Paulo - Brazil

^[10] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA - USA

^[11] Imperial Coll London, Sch Publ Hlth, Dept Infect Dis Epidemiol, London - England

^[12] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil

^[13] Univ Fed ABC, Ctr Math Comp & Cognit, Sao Paulo - Brazil

^[14] Univ Oxford, Latin Amer Ctr, Oxford Sch Global & Area Studies, Oxford - England

^[15] Univ Calif San Francisco, San Francisco, CA 94143 - USA

^[16] Vitalant Res Inst, San Francisco, CA - USA

^[17] Fundacao Oswaldo Cruz Fiocruz, Inst Goncalo Moniz, Salvador, BA - Brazil

^[18] Univ Oxford, Dept Zool, Oxford - England

^[19] Inst Appl Econ Res IPEA, Brasilia, DF - Brazil

^[20] Parag, Kris, V, Imperial Coll London, MRC Ctr Global Infect Dis Anal, J IDEA, London - England

• Tipo de documento: Artigo Científico
• Fonte: Science; v. 371, n. 6526, p. 288+, JAN 15 2021.
• Citações Web of Science: 16

Resumo

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly in Manaus, the capital of Amazonas state in northern Brazil. The attack rate there is an estimate of the final size of the largely unmitigated epidemic that occurred in Manaus. We use a convenience sample of blood donors to show that by June 2020, 1 month after the epidemic peak in Manaus, 44% of the population had detectable immunoglobulin G (IgG) antibodies. Correcting for cases without a detectable antibody response and for antibody waning, we estimate a 66% attack rate in June, rising to 76% in October. This is higher than in Sao Paulo, in southeastern Brazil, where the estimated attack rate in October was 29%. These results confirm that when poorly controlled, COVID-19 can infect a large proportion of the population, causing high mortality. (AU)

• Processo FAPESP: 18/14389-0 - Centro Conjunto Brasil-Reino Unido para Descoberta, Diagnóstico, Genômica e Epidemiologia de Arbovírus (CADDE)
• Beneficiário: Ester Cerdeira Sabino
• Modalidade de apoio: Auxílio à Pesquisa - Temático