Antiproliferative activity from Aldama arenaria (Baker) E. E. Schill. & Panero

Autor(es)

de Oliveira, Adriana da S. S. ^{[1, 2, 3]} ; Imamura, Paulo M. ^[2] ; Ruiz, Ana L. T. G. ^[3] ; Appezzato-da-Gloria, Beatriz ^[4] ; de Oliveira, Tuane ^[1] ; Garcia, Vera L. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Quim, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, Paulinia, SP - Brazil

^[4] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz ESALQ, Piracicaba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas; v. 20, n. 1, p. 51-60, JAN 2021.
• Citações Web of Science: 0

Resumo

Chloroform extract (CE) and fractions obtained from Aldama arenaria roots were evaluated for their in vitro antiproliferative activity against 10 human tumor cell lines {[}leukemia (K-562), breast (MCF-7), ovary expressing a multidrug-resistant phenotype (NCI/ADR-RES), melanoma (UACC-62), lung (NCI-H460), prostate (PC-3), colon (HT29), ovary (OVCAR-3), glioma (U251), and kidney (786-0)]. CE presented weak to moderate antiproliferative activity (mean log GI(50) 1.07), whereas fractions 3 and 4, enriched with pimarane-type diterpenes {[}ent-pimara-8(14),15-dien-19-oic acid and ent-8(14),15-pimaradien-3 beta-ol], presented moderate to potent activity for most cell lines, with mean log 0150 of 0.62 and 0.59, respectively. The results showed promising in vitro antiproliferative action of the samples obtained from A. arenaria, with the best results for NCI/ADR-RES, HT29, and OVCAR-3, and TGI values ranging from 5.95 to 28.71 mu g.mL-1, demonstrating that compounds of this class may be potential prototypes for the discovery of new therapeutic agents. (AU)

• Processo FAPESP: 10/51454-3 - Estudos morfoanatômicos, metabolômicos e moleculares como subsídios à sistemática de espécies de Asteraceae e acesso ao seu potencial farmacológico
• Beneficiário: Beatriz Appezzato da Glória
• Modalidade de apoio: Auxílio à Pesquisa - Temático