| Full text | |
| Author(s): |
de Oliveira, Adriana da S. S.
[1, 2, 3]
;
Imamura, Paulo M.
[2]
;
Ruiz, Ana L. T. G.
[3]
;
Appezzato-da-Gloria, Beatriz
[4]
;
de Oliveira, Tuane
[1]
;
Garcia, Vera L.
[1, 3]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Quim, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, Paulinia, SP - Brazil
[4] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz ESALQ, Piracicaba, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas; v. 20, n. 1, p. 51-60, JAN 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Chloroform extract (CE) and fractions obtained from Aldama arenaria roots were evaluated for their in vitro antiproliferative activity against 10 human tumor cell lines {[}leukemia (K-562), breast (MCF-7), ovary expressing a multidrug-resistant phenotype (NCI/ADR-RES), melanoma (UACC-62), lung (NCI-H460), prostate (PC-3), colon (HT29), ovary (OVCAR-3), glioma (U251), and kidney (786-0)]. CE presented weak to moderate antiproliferative activity (mean log GI(50) 1.07), whereas fractions 3 and 4, enriched with pimarane-type diterpenes {[}ent-pimara-8(14),15-dien-19-oic acid and ent-8(14),15-pimaradien-3 beta-ol], presented moderate to potent activity for most cell lines, with mean log 0150 of 0.62 and 0.59, respectively. The results showed promising in vitro antiproliferative action of the samples obtained from A. arenaria, with the best results for NCI/ADR-RES, HT29, and OVCAR-3, and TGI values ranging from 5.95 to 28.71 mu g.mL-1, demonstrating that compounds of this class may be potential prototypes for the discovery of new therapeutic agents. (AU) | |
| FAPESP's process: | 10/51454-3 - Morphoanatomical, metabolomic and molecular studies as subsidies to the systematic of Asteraceae species and access to their pharmacological potential |
| Grantee: | Beatriz Appezzato da Glória |
| Support Opportunities: | Research Projects - Thematic Grants |