Gut-to-brain signals in feeding control

Autor(es)

Moura-Assis, Alexandre ^{[1, 2]} ; Friedman, Jeffrey M. ^{[3, 2]} ; Velloso, Licio A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Lab Cell Signaling, Campinas, SP - Brazil

^[2] Rockefeller Univ, Lab Mol Genet, New York, NY 10065 - USA

^[3] Howard Hughes Med Inst, New York, NY - USA

• Tipo de documento: Artigo de Revisão
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM; v. 320, n. 2, p. E326-E332, FEB 2021.
• Citações Web of Science: 0

Resumo

Interoceptive signals from gut and adipose tissue and sensory cues from the environment are integrated by hubs in the brain to regulate feeding behavior and maintain homeostatic control of body weight. In vivo neural recordings have revealed that these signals control the activity of multiple layers of hunger neurons and eating is not only the result of feedback correction to a set point, but can also be under the influence of anticipatory regulations. A series of recent technical developments have revealed how peripheral and sensory signals, in particular, from the gut are conveyed to the brain to integrate neural circuits. Here, we describe the mechanisms involved in gastrointestinal stimulation by nutrients and how these signals act on the hindbrain to generate motivated behaviors. We also consider the organization of multidirectional intra- and extrahypothalamic circuits and how this has created a framework for understanding neural control of feeding. (AU)

• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs