Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review

Autor(es)

Campos Aguiar, Anna Caroline ^[1] ; Parisi, Julia Risso ^[1] ; Granito, Renata Neves ^[1] ; Freitas de Sousa, Lorena Ramos ^[2] ; Muniz Renno, Ana Claudia ^[1] ; Gazarini, Marcos Leoni ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil

^[2] Fed Univ Goias UFG UFCAT, Special Acad Unit Chem, BR-75704020 Catalao, Go - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: MARINE DRUGS; v. 19, n. 3 MAR 2021.
• Citações Web of Science: 0

Resumo

Malaria is an infectious disease caused by protozoan parasites of the Plasmodium genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource of bioactive compounds and secondary metabolites from different marine organisms. This systematic review of the literature focuses on the advances achieved in the search for new antimalarials from marine sponges, which are ancient organisms that developed defense mechanisms in a hostile environment. The principal inclusion criterion for analysis was articles with compounds with IC50 below 10 mu M or 10 mu g/mL against P. falciparum culture. The secondary metabolites identified include alkaloids, terpenoids, polyketides endoperoxides and glycosphingolipids. The structural features of active compounds selected in this review may be an interesting scaffold to inspire synthetic development of new antimalarials for selectively targeting parasite cell metabolism. (AU)

• Processo FAPESP: 19/19708-0 - Identificação de novos compostos antimaláricos: uma estratégia multidisciplinar visando a busca por classes ativas contra novos alvos moleculares e diferentes estágios de vida do Plasmodium spp
• Beneficiário: Anna Caroline Campos Aguiar
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores