Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation

Autor(es)

de Oliveira, Lilian Gomes ^{[1, 2]} ; Angelo, Yan de Souza ^{[1, 2]} ; Iglesias, Antonio H. ^[3] ; Peron, Jean Pierre Schatzmann ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Neuroimmune Interact Lab, Dept Immunol, Inst Biomed Sci ICB 4, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Neuroimmunol Arboviruses Lab, Sci Platform Pasteur USP, Sao Paulo - Brazil

^[3] Loyola Univ Chicago, Loyola Univ Med Ctr, Stritch Sch Med, Chicago, IL 60660 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 12, MAR 16 2021.
• Citações Web of Science: 0

Resumo

Neuroinflammatory and neurodegenerative diseases are a major public health problem worldwide, especially with the increase of life-expectancy observed during the last decades. For many of these diseases, we still lack a full understanding of their etiology and pathophysiology. Nonetheless their association with mitochondrial dysfunction highlights this organelle as an important player during CNS homeostasis and disease. Markers of Parkinson (PD) and Alzheimer (AD) diseases are able to induce innate immune pathways induced by alterations in mitochondrial Ca2+ homeostasis leading to neuroinflammation. Additionally, exacerbated type I IFN responses triggered by mitochondrial DNA (mtDNA), failures in mitophagy, ER-mitochondria communication and mtROS production promote neurodegeneration. On the other hand, regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of IL-10 and reduction of TNF-alpha secretion, increased cell viability and diminished cell injury in addition to reduced oxidative stress. Thus, although previously solely seen as power suppliers to organelles and molecular processes, it is now well established that mitochondria have many other important roles, including during immune responses. Here, we discuss the importance of these mitochondrial dynamics during neuroinflammation, and how they correlate either with the amelioration or worsening of CNS disease. (AU)

• Processo FAPESP: 17/22504-1 - O papel dos receptores TAM e seus ligantes, Gas6 e Pros1, na Síndrome Congênita do Zika Vírus Experimental
• Beneficiário: Jean Pierre Schatzmann Peron
• Modalidade de apoio: Auxílio à Pesquisa - Regular