AIDS incidence and survival in a hospital-based cohort of HIV-positive patients from Sao Paulo, Brazil: The role of IFN-lambda 4 polymorphisms

Autor(es):Mostrar menos -

da Silva Prates, Gabriela ^[1] ; Malta, Fernanda M. ^[2] ; de Toledo Goncalves, Fernanda ^[3] ; Monteiro, Mariana A. ^{[1, 4]} ; Fonseca, Luiz Augusto M. ^[1] ; R. Veiga, Ana Paula ^[4] ; M. C. Magri, Marcello ^[4] ; Duarte, Alberto J. S. ^{[1, 4]} ; Casseb, Jorge ^{[1, 4]} ; Assone, Tatiane ; GRP, ADEE 3002

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Fac Med FMUSP, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med FMUSP, Dept Gastroenterol, Lab Gastroenterol & Hepatol Trop, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Fac Med FMUSP, Dept Med Legal, Etica Med & Med Social & Trabalho, Sao Paulo, SP - Brazil

^[4] Fac Med FMUSP, Hosp Clin, Dept Dermatol, Ambulatorio Dermatol & Imunodeficie, Rua Dr Eneas Carvalho Aguiar 500, BR-05403000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Medical Virology; v. 93, n. 6, p. 3601-3606, JUN 2021.
• Citações Web of Science: 0

Resumo

Few studies have reported the prognosis of human immunodeficiency virus (HIV)-positive patients followed for a long time in Brazil, particularly those including pre and post-HAART eras. The polymorphisms of interferon (IFN)-lambda 4 have been postulated as possibly associated with the pathogenesis of HIV infection. The aim of this study was to describe the incidence and mortality from a cohort of HIV-positive patients as well as whether IFN-lambda 4 gene polymorphisms (SNP rs8099917 and SNP rs12979860) were associated with HIV/acquired immune deficiency syndrome (AIDS) progression. We followed 402 patients for up to 30 years; 347 of them began follow-up asymptomatic, without any AIDS-defining opportunistic disease and/or a lymphocytes T CD4+ count of 350 cells/mm(3)or lower. We determined the probability of the asymptomatic subjects to remain AIDS-free, and the risk of death for those entering the study already with an AIDS diagnosis, as well as for subjects developing AIDS during follow-up. We compared the prognosis of patients with two different polymorphisms for the genes encoding for IFN-lambda 4, variants rs8099917 and rs12979860. The follow-up time of the 347 asymptomatic-at-entry subjects was 3687 person-years. IFN-lambda 4 rs8099917 polymorphisms were not associated with AIDS progression, but IFN-lambda 4 rs12979860 wild type genotype (CC) was associated with higher mortality compared to CT and TT, with an increased probability of death from AIDS (P = .01). In conclusion, genetic variations in IFN-lambda 4 on rs12979860 polymorphisms in HIV-infected patients may drive mortality risk. (AU)

• Processo FAPESP: 16/03025-2 - Identificação de polimorfismos relacionados à mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP)
• Beneficiário: Tatiane Assone Casseb
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/18522-0 - Análise genômica, transcriptômica e metabolômica integrada de mecanismos (imuno) patogênicos que conduzem à paraparesia espástica tropical / mielopatia associada ao HTLV-1 (HAM/TSP)
• Beneficiário: Tatiane Assone Casseb
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 17/08320-5 - Identificação de polimorfismos relacionados à mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP)
• Beneficiário: Jorge Simao do Rosario Casseb
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/07239-2 - Incidência, fatores de risco, mecanismos patogênicos e prevenção de distúrbios neurocognitivos (HAND) entre indivíduos infectados com HIV-1
• Beneficiário: Jorge Simao do Rosario Casseb
• Modalidade de apoio: Auxílio à Pesquisa - Temático