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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

AIDS incidence and survival in a hospital-based cohort of HIV-positive patients from Sao Paulo, Brazil: The role of IFN-lambda 4 polymorphisms

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Author(s):
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da Silva Prates, Gabriela [1] ; Malta, Fernanda M. [2] ; de Toledo Goncalves, Fernanda [3] ; Monteiro, Mariana A. [1, 4] ; Fonseca, Luiz Augusto M. [1] ; R. Veiga, Ana Paula [4] ; M. C. Magri, Marcello [4] ; Duarte, Alberto J. S. [1, 4] ; Casseb, Jorge [1, 4] ; Assone, Tatiane ; GRP, ADEE 3002
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Fac Med FMUSP, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med FMUSP, Dept Gastroenterol, Lab Gastroenterol & Hepatol Trop, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med FMUSP, Dept Med Legal, Etica Med & Med Social & Trabalho, Sao Paulo, SP - Brazil
[4] Fac Med FMUSP, Hosp Clin, Dept Dermatol, Ambulatorio Dermatol & Imunodeficie, Rua Dr Eneas Carvalho Aguiar 500, BR-05403000 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Medical Virology; v. 93, n. 6, p. 3601-3606, JUN 2021.
Web of Science Citations: 0
Abstract

Few studies have reported the prognosis of human immunodeficiency virus (HIV)-positive patients followed for a long time in Brazil, particularly those including pre and post-HAART eras. The polymorphisms of interferon (IFN)-lambda 4 have been postulated as possibly associated with the pathogenesis of HIV infection. The aim of this study was to describe the incidence and mortality from a cohort of HIV-positive patients as well as whether IFN-lambda 4 gene polymorphisms (SNP rs8099917 and SNP rs12979860) were associated with HIV/acquired immune deficiency syndrome (AIDS) progression. We followed 402 patients for up to 30 years; 347 of them began follow-up asymptomatic, without any AIDS-defining opportunistic disease and/or a lymphocytes T CD4+ count of 350 cells/mm(3)or lower. We determined the probability of the asymptomatic subjects to remain AIDS-free, and the risk of death for those entering the study already with an AIDS diagnosis, as well as for subjects developing AIDS during follow-up. We compared the prognosis of patients with two different polymorphisms for the genes encoding for IFN-lambda 4, variants rs8099917 and rs12979860. The follow-up time of the 347 asymptomatic-at-entry subjects was 3687 person-years. IFN-lambda 4 rs8099917 polymorphisms were not associated with AIDS progression, but IFN-lambda 4 rs12979860 wild type genotype (CC) was associated with higher mortality compared to CT and TT, with an increased probability of death from AIDS (P = .01). In conclusion, genetic variations in IFN-lambda 4 on rs12979860 polymorphisms in HIV-infected patients may drive mortality risk. (AU)

FAPESP's process: 16/03025-2 - Identification of polymorphisms related to HTLV-1 associated myelopathy / tropical spastic paraparesis (HAM / TSP)
Grantee:Tatiane Assone Casseb
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/18522-0 - An integrated genomic, transcriptomic and metabolomic analysis of (immuno)pathogenic mechanisms leading to HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Grantee:Tatiane Assone Casseb
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 17/08320-5 - Polymorphisms Identification related to HTLV-1 associated myelopathy / tropical spastic paraparesis (HAM / TSP)
Grantee:Jorge Simao do Rosario Casseb
Support Opportunities: Regular Research Grants
FAPESP's process: 18/07239-2 - Incidence, risk factors, and pathogenic mechanism of neurocognitive disorders (HAND) among HIV-1-infected subjects
Grantee:Jorge Simao do Rosario Casseb
Support Opportunities: Research Projects - Thematic Grants