Incidence, risk factors, and pathogenic mechanism of neurocognitive disorders (HAND) among HIV-1-infected subjects

• Grant number: 18/07239-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: October 01, 2019
• End date: September 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Jorge Simao do Rosario Casseb
• Grantee: Jorge Simao do Rosario Casseb
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Augusto Cesar Penalva de Oliveira ; Shirley Cavalcante Vasconcelos ; Simone Kashima Haddad
• Associated research grant(s): 20/05984-2 - Acute neurological manifestations associated with SARS-CoV-2 virus, AP.R
• Associated scholarship(s): 24/20627-2 - Incidence, risk factors, and pathogenic mechanisms in HIV-1-associated neurocognitive disorders (HAND), BP.TT; 23/16832-7 - Incidence, risk factors, and pathogenic mechanisms in HIV-1-associated neurocognitive disorders (HAND), BP.TT; 22/00132-3 - Incidence, risk factors, and pathogenic mechanisms in HIV-1-associated neurocognitive disorders (HAND), BP.PD; 21/12316-9 - Deciphering immune biomarkers of HTLV-1 infection and clinical outcome, BP.IC; 20/09887-1 - Incidence, risk factors, and pathogenic mechanisms in HIV-1-associated neurocognitive disorders (HAND), BP.TT

Abstract

The prognosis of HAND presents a difficult approach, especially in the first stage of the disease, which may prevent early treatment and prevention of more severe forms. HIV can remain latent in the CNS for many years and subclinical infection associated with comorbidities (e.g., metabolic syndrome, drug use and Hepatitis C), as well as lead to immune activation, and low-grade chronic immune inflammation. Immunological effects and the possibility of developing neurocognitive changes due to HIV infection are not ruled out, despite the suppression of viral RNA in peripheral blood and cerebrospinal fluid (CSF). Some authors argue that a higher rate of drug penetration (CPE) in the CNS could be associated with a greater chance of undetectable viral load in the CNS, as well as better cognitive functioning. This proposal aims to combine several previous studies that describe virological and immunological factors that could be considered as potential markers for diagnosis as well as more recently identified factors. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARCUSSO, ROSA MARIA N.; VAN WEYENBERGH, JOHAN; LUISI DE MOURA, JOAO VICTOR; DAHY, FLAVIA ESPER; BRASIL MATOS, ALINE DE MOURA; HAZIOT, MICHEL E. J.; VIDAL, JOSE E.; FONSECA, LUIZ AUGUSTO M.; SMID, JERUSA; ASSONE, TATIANE; et al. Dichotomy in Fatal Outcomes in a Large Cohort of People Living with HTLV-1 in Sao Paulo, Brazil. PATHOGENS, v. 9, n. 1, JAN 2020. (18/07239-2, 17/08320-5, 16/03025-2)

KOMNINAKIS, SHIRLEY VASCONCELOS; DOMINGUES, WILSON; SANABANI, SABRI SAEED; FOLGOSI, VICTOR ANGELO; BARBOSA, IGOR NEVES; CASSEB, JORGE. CRISPR/CAS as a Powerful Tool for Human Immunodeficiency Virus Cure: A Review. AIDS Research and Human Retroviruses, v. 40, n. 6, p. 13-pg., 2024-02-02. (18/07239-2)

DA SILVA PRATES, GABRIELA; MALTA, FERNANDA M.; DE TOLEDO GONCALVES, FERNANDA; MONTEIRO, MARIANA A.; FONSECA, LUIZ AUGUSTO M.; R. VEIGA, ANA PAULA; M. C. MAGRI, MARCELLO; DUARTE, ALBERTO J. S.; CASSEB, JORGE; ASSONE, TATIANE; et al. AIDS incidence and survival in a hospital-based cohort of HIV-positive patients from Sao Paulo, Brazil: The role of IFN-lambda 4 polymorphisms. Journal of Medical Virology, v. 93, n. 6, p. 3601-3606, JUN 2021. (16/03025-2, 19/18522-0, 17/08320-5, 18/07239-2)

FERREIRA, CLAUDETE M. S.; SUNADA, NOEMIA M. O.; CASSEB, JORGE. T-lymphocyte activation markers in patients with HIV-1-associated neurocognitive disorder. JOURNAL OF NEUROVIROLOGY, v. N/A, p. 6-pg., 2022-05-08. (18/07239-2)

ROCHA-JUNIOR, MAURICIO CRISTIANO; RODRIGUES, EVANDRA STRAZZA; SLAVOV, SVETOSLAV NANEV; ASSONE, TATIANE; PEDRESCHI, MAIRA; DE LA ROQUE, DEBORA GLENDA LIMA; SOUSA, MAISA; OLAVARRIA, VIVIANA; GALVAO-CASTRO, BERNARDO; DA FONSECA, BENEDITO ANTONIO LOPES; et al. Rapid and Sensitive Qualitative Duoplex Real-Time PCR Method for Discriminatory and Confirmatory Diagnosis of HTLV-1 and HTLV-2 Infections: Brazilian Multicentric Study. FRONTIERS IN MEDICINE, v. 9, p. 9-pg., 2022-06-09. (13/08135-2, 18/07239-2)

ALMEIDA-AFONSO, ROSA; FINAMOR, DANILO; FONSECA, LUIZ AUGUSTO M.; ROCHA VEIGA, ANA P.; MONTEIRO, MARIANA A.; MAGRI, MARCELLO; DUARTE, ALBERTO J. S.; CASSEB, JORGE; CLINICAS, HOSP; DERMATOL, SERV; et al. Efficacy of vitamin D supplementation among persons living with HIV/AIDS in São Paulo city, Brazil. Brazilian Journal of Infectious Diseases, v. 25, n. 3, MAY-JUN 2021. (18/07239-2)

GASCON, MARIA RITA POLO; DE OLIVEIRA, GIOVANA S.; LAURENCE, PAULO GUIRRO; GUALQUI, CAROLINA FERNANDES; DE OLIVEIRA, AUGUSTO CESAR PENALVA; SMID, JERUSA; FONSECA, LUIZ A. M.; CASSEB, JORGE; MACEDO, ELIZEU COUTINHO. Neuropsychological profile of patients with infectious disease: characterization and comparison of patients with HIV, HTLV, and HCV. JOURNAL OF NEUROVIROLOGY, v. N/A, p. 8-pg., 2022-12-17. (18/07239-2)

ASSONE, TATIANE; MENEZES, SORAYA MARIA; GONCALVES, FERNANDA DE TOLEDO; FOLGOSI, VICTOR ANGELO; PRATES, GABRIELA DA SILVA; DIERCKX, TIM; BRAZ, MARCOS; SMID, JERUSA; HAZIOT, MICHEL E.; MARCUSSO, ROSA M. N.; et al. Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation. JOURNAL OF NEUROINFLAMMATION, v. 19, n. 1, p. 15-pg., 2022-12-08. (17/08320-5, 16/03025-2, 18/07239-2)

DOMINGUES, WILSON; FOLGOSI, VICTOR ANGELO; SANABANI, SABRI SAEED; LEITE JUNIOR, PEDRO DOMINGOS; ASSONE, TATIANE; CASSEB, JORGE. Novel approaches for HTLV-1 therapy: innovative applications of CRISPR-Cas9. Revista do Instituto de Medicina Tropical de São Paulo, v. 66, p. 9-pg., 2024-01-01. (18/07239-2, 22/00132-3, 23/14320-9)