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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Evaluation of Guided Bone Regeneration in Critical Defects Using Bovine and Porcine Collagen Membranes: Histomorphometric and Immunohistochemical Analyses

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Autor(es):
Ramires, Guilherme A. D. [1] ; Helena, Julia Taino [1] ; Oliveira, Julio C. S. De [1, 2] ; Faverani, Leonardo Perez [1] ; Bassi, Ana Paula F. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Aracatuba Dent Sch UNESP, Dept Diag & Surg, BR-16015050 Aracatuba - Brazil
[2] Ceuma Univ, Dept Dent, BR-65075120 Sao Luis, Maranhao - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF BIOMATERIALS; v. 2021, MAR 30 2021.
Citações Web of Science: 0
Resumo

Guided bone regeneration (GBR) is a technique used to facilitate bone regeneration, which uses a biocompatible membrane acting as a physical barrier to prevent the adjacent connective tissue from invading the bone defect. The aim of this study was to evaluate and compare the effectiveness of bovine and porcine collagenous membranes as barriers to connective tissue invasion during the repair of critical bone defects in rat calvaria, using histological, histometric, and immunohistochemical analyses. For this study, 72 rats were divided into three groups: clot group (CG), bovine collagen group (BCG), and porcine collagen group (PCG). Analyses were performed on days 7, 15, 30, and 60. The histological results showed that the PCG exhibited bone neoformation starting from day 7, and after 30 days of repair, the surgical defect was completely filled in some animals. For the BCG, there was little bone neoformation activity in the initial periods, and from day 30 onwards, there was an increase in bone neoformation, with a greater increase on day 60. The data obtained in the histometric analysis reveal that, on day 30, the neoformed bone area did not vary greatly between the PCG and the BCG, though both varied from the CG. By day 60, the PCG presented a greater area of neoformation than the BCG. These results were corroborated by the immunohistochemistry results. In view of the results obtained, it can be concluded that all membranes studied in this research promoted GBR. (AU)

Processo FAPESP: 16/12053-0 - Avaliação do processo de reparo em defeitos de calvária de ratos com o uso de duas membranas de cortical bovina com diferentes espessuras e a membrana de colágeno porcino: análise histológica, histométrica e imunoistoquímica
Beneficiário:Tamires Melo Francati
Linha de fomento: Bolsas no Brasil - Iniciação Científica