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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of Guided Bone Regeneration in Critical Defects Using Bovine and Porcine Collagen Membranes: Histomorphometric and Immunohistochemical Analyses

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Ramires, Guilherme A. D. [1] ; Helena, Julia Taino [1] ; Oliveira, Julio C. S. De [1, 2] ; Faverani, Leonardo Perez [1] ; Bassi, Ana Paula F. [1]
Total Authors: 5
[1] Aracatuba Dent Sch UNESP, Dept Diag & Surg, BR-16015050 Aracatuba - Brazil
[2] Ceuma Univ, Dept Dent, BR-65075120 Sao Luis, Maranhao - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 0

Guided bone regeneration (GBR) is a technique used to facilitate bone regeneration, which uses a biocompatible membrane acting as a physical barrier to prevent the adjacent connective tissue from invading the bone defect. The aim of this study was to evaluate and compare the effectiveness of bovine and porcine collagenous membranes as barriers to connective tissue invasion during the repair of critical bone defects in rat calvaria, using histological, histometric, and immunohistochemical analyses. For this study, 72 rats were divided into three groups: clot group (CG), bovine collagen group (BCG), and porcine collagen group (PCG). Analyses were performed on days 7, 15, 30, and 60. The histological results showed that the PCG exhibited bone neoformation starting from day 7, and after 30 days of repair, the surgical defect was completely filled in some animals. For the BCG, there was little bone neoformation activity in the initial periods, and from day 30 onwards, there was an increase in bone neoformation, with a greater increase on day 60. The data obtained in the histometric analysis reveal that, on day 30, the neoformed bone area did not vary greatly between the PCG and the BCG, though both varied from the CG. By day 60, the PCG presented a greater area of neoformation than the BCG. These results were corroborated by the immunohistochemistry results. In view of the results obtained, it can be concluded that all membranes studied in this research promoted GBR. (AU)

FAPESP's process: 16/12053-0 - Evaluation of repair process in calvarial defects in rats using two bovine cortical membranes with different thickness and porcine collagen membrane: histological analysis, histometric and immunohistochemistry
Grantee:Tamires Melo Francati
Support type: Scholarships in Brazil - Scientific Initiation