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Bone neoformation in critical defects in rat calvaria from bovine collagen membrane: histomorphometric and immunohistochemistry analysis

Grant number: 18/05973-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2018
Effective date (End): August 31, 2019
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Ana Paula Farnezi Bassi
Grantee:Julia Taino Helena
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The use of membranes that help in guided bone regeneration process (ROG) is also a part of compatible biomaterial studies that help this repair process. Objective: Evaluating and comparing through microscopic and histomorphometric study the guided bone regeneration using different sources of membranes in critical defects created in rat calvaria. Materials and methods: It will be used 72 Wistar Albinus rats divided into 3 groups, with 6 animals for each group: control group only with clot; group that received collagen membrane of bovine group (Lumina Coat®); and collagen membrane of porcine group (Bio-Gide®). Six animals from each group will be sacrificed at the 7, 15, 30 and 60. After, it will be carried out laboratory formalities and submitted to histologic histomorphometric and immunohistochemical analysis.

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