Strategies for Cancer Treatment Based on Photonic Nanomedicine

Autor(es)

de Oliveira, Sueli Aparecida ^[1] ; Borges, Roger ^[2] ; dos Santos Rosa, Derval ^[1] ; de Souza, Ana Carolina Santos ^[2] ; Seabra, Amedea B. ^[2] ; Baino, Francesco ^[3] ; Marchi, Juliana ^[2]

Afiliação do(s) autor(es)

^[1] Fed Univ ABC, Ctr Engn Modelagem & Ciencias Sociais Aplicadas, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[2] Fed Univ ABC, Ctr Ciencias Nat & Humanas, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[3] Politecn Torino, Inst Mat Phys & Engn, Dept Appl Sci & Technol, I-10129 Turin - Italy

• Tipo de documento: Artigo de Revisão
• Fonte: MATERIALS; v. 14, n. 6 MAR 2021.
• Citações Web of Science: 0

Resumo

Traditional cancer treatments, such as surgery, radiotherapy, and chemotherapy, are still the most effective clinical practice options. However, these treatments may display moderate to severe side effects caused by their low temporal or spatial resolution. In this sense, photonic nanomedicine therapies have been arising as an alternative to traditional cancer treatments since they display more control of temporal and spatial resolution, thereby yielding fewer side effects. In this work, we reviewed the challenge of current cancer treatments, using the PubMed and Web of Science database, focusing on the advances of three prominent therapies approached by photonic nanomedicine: (i) photothermal therapy; (ii) photodynamic therapy; (iii) photoresponsive drug delivery systems. These photonic nanomedicines act on the cancer cells through different mechanisms, such as hyperthermic effect and delivery of chemotherapeutics and species that cause oxidative stress. Furthermore, we covered the recent advances in materials science applied in photonic nanomedicine, highlighting the main classes of materials used in each therapy, their applications in the context of cancer treatment, as well as their advantages, limitations, and future perspectives. Finally, although some photonic nanomedicines are undergoing clinical trials, their effectiveness in cancer treatment have already been highlighted by pre-clinical studies. (AU)

• Processo FAPESP: 16/16512-9 - Desenvolvimento de um sistema carreador para liberação simultânea de fármaco e íons provenientes de vidros biocompatíveis a partir de uma matriz de hidrogel com os objetivos de auxiliar no tratamento de câncer ósseo e estimular a reparação óssea
• Beneficiário: Juliana Marchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular