Adipose tissue radiodensity: A new prognostic biomarker in people with multiple myeloma

Autor(es):Mostrar menos -

da Cunha, Jr., Ademar Dantas ^{[1, 2, 3]} ; Silveira, Marina Nogueira ^[1] ; Takahashi, Maria Emilia Seren ^[4] ; Souza, Edna Marina de ^[5] ; Mosci, Camila ^[6] ; Ramos, Celso Dario ^[6] ; Brambilla, Sandra Regina ^[1] ; Pericole, Fernando Vieira ^[7] ; Prado, Carla M. ^[8] ; Mendes, Maria Carolina Santos ^[1] ; Carvalheira, Jose Barreto Campello ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Div Oncol, Dept Internal Med, Fac Med Sci, Campinas - Brazil

^[2] Uniao Oeste Estudos & Combate Canc UOPECCAN, Canc Hosp Cascavel, Hematol & Oncol Clin, Cascavel - Brazil

^[3] State Univ Western Parana UNIOESTE, Dept Internal Med, Cascavel - Brazil

^[4] State Univ Campinas UNICAMP, Gleb Wataghin Phys Inst, Campinas - Brazil

^[5] State Univ Campinas UNICAMP, Ctr Biomed Engn, Campinas - Brazil

^[6] State Univ Campinas UNICAMP, Div Nucl Med, Dept Radiol, Campinas - Brazil

^[7] State Univ Campinas UNICAMP, Hematol & Blood Transfus Ctr, Campinas - Brazil

^[8] Univ Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB - Canada

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 86, JUN 2021.
• Citações Web of Science: 0

Resumo

Objectives: Standard prognostic markers based on individual characteristics of individuals with multiple myeloma (MM) remain scarce. Body-composition features have often been associated with survival outcomes in different cancers. However, the association of adipose tissue radiodensity with MM prognosis has not yet, to our knowledge, been explored. Methods: Computed tomography at the third lumbar vertebra was used for body-composition analysis, including adipose tissue radiodensity, in 91 people with MM. Additionally, fludeoxyglucose F 18 (F-18-FDG) positron emission tomography was used to assess adipose tissue F-18-FDG uptake. Proinflammatory cytokine and adipokine levels were measured. Results: Event-free survival and overall survival were both shorter in participants with high subcutaneous adipose tissue (SAT) radiodensity. Those in the highest SAT radiodensity tertile had an independently higher risk for both overall survival (hazard ratio, 4.55; 95% confidence interval, 1.26-16.44; P-trend = 0.036) and event-free survival (hazard ratio, 3.08; 95% confidence interval, 1.02-9.27; P-trend = 0.035). Importantly, higher SAT radiodensity was significantly correlated with increased F-18-FDG adipose tissue uptake and proinflammatory cytokine (tumor necrosis factor and interleukin-6) levels, and with decreased leptin levels. Conclusions: SAT radiodensity may serve as a biomarker to predict host-related metabolic and proinflammatory milieu, which ultimately correlates with MM prognosis. (C) 2021 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 18/23428-0 - Caracterização do perfil metabólico de pacientes com câncer colorretal que diferem quanto à sarcopenia
• Beneficiário: José Barreto Campello Carvalheira
• Modalidade de apoio: Auxílio à Pesquisa - Regular