The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

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Constable, Annie M. ^{[1, 2]} ; Porter, Josie E. ^[1] ; Benger, Danielle ^[1] ; Vlachopoulos, Dimitris ^[1] ; Barker, Alan R. ^[1] ; Moore, Sarah A. ^[3] ; Soininen, Sonja ^{[2, 4]} ; Haapala, Eero A. ^{[2, 5]} ; Westgate, Kate ^[6] ; Brage, Soren ^[6] ; Agostinete, Ricardo R. ^[7] ; Fernandes, Romulo A. ^[7] ; Lakka, Timo A. ^{[2, 8, 9]}

Afiliação do(s) autor(es)

^[1] Univ Exeter, Childrens Hlth & Exercise Res Ctr, Sport & Hlth Sci, Exeter EX1 1TX, Devon - England

^[2] Univ Eastern Finland, Inst Biomed, Kuopio Campus, FI-70211 Kuopio - Finland

^[3] Dalhousie Univ, Sch Hlth & Human Performance, Halifax, NS B3H 4R2 - Canada

^[4] Social & Hlth Ctr, City Of Varkaus 78300 - Finland

^[5] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla 40014 - Finland

^[6] Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge CB2 0SL - England

^[7] Sao Paulo State Univ, Dept Phys Educ, Lab InVest Exercise LIVE, UNESP, BR-19060900 Presidente Prudente - Brazil

^[8] Univ Eastern Finland, Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio 70210 - Finland

^[9] Kuopio Res Inst Exercise Med, Fdn Res Hlth Exercise & Nutr, Kuopio 70100 - Finland

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; v. 18, n. 10 MAY 2021.
• Citações Web of Science: 0

Resumo

Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (beta = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (beta = -0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty. (AU)

• Processo FAPESP: 17/09182-5 - Impacto da prática esportiva realizada em meio líquido sobre parâmetros de formação óssea de adolescentes: abcd - growth study
• Beneficiário: Ricardo Ribeiro Agostinete
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/24164-6 - Adaptações longitudinais na força e geometria óssea de adolescentes engajados em seis diferentes modalidades esportivas abcd-growth study
• Beneficiário: Ricardo Ribeiro Agostinete
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado