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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Clinical Characteristics and Survival Analysis in Frequent Alcohol Consumers With COVID-19

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Autor(es):
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Alberca, Ricardo Wesley [1] ; Rigato, Paula Ordonhez [2] ; Leuzzi Ramos, Yasmim Alefe [1] ; Emidio Teixeira, Franciane Mouradian [3, 1] ; Calvielli Branco, Anna Claudia [3, 1] ; Fernandes, Iara Grigoletto [1] ; Pietrobon, Anna Julia [3, 1] ; da Silva Duarte, Alberto Jose [1] ; Aoki, Valeria [1] ; Orfali, Raquel Leao [1] ; Sato, Maria Notomi [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med FMUSP, Inst Med Trop, Dept Dermatol, Lab Dermatol & Imunodeficiencias LI, Sao Paulo - Brazil
[2] Adolfo Lutz Inst, Immunol Ctr, Tech Div Med Biol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN NUTRITION; v. 8, JUN 2 2021.
Citações Web of Science: 0
Resumo

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can generate a systemic disease named coronavirus disease-2019 (COVID-19). Currently, the COVID-19 pandemic has killed millions worldwide, presenting huge health and economic challenges worldwide. Several risk factors, such as age, co-infections, metabolic syndrome, and smoking have been associated with poor disease progression and outcomes. Alcohol drinking is a common social practice among adults, but frequent and/or excessive consumption can mitigate the anti-viral and anti-bacterial immune responses. Therefore, we investigated if patients with self-reported daily alcohol consumption (DAC) presented alteration in the immune response to SARS-CoV-2. We investigated 122 patients with COVID-19 (101 male and 46 females), in which 23 were patients with DAC (18 men and 5 women) and 99 were non-DAC patients (58 men and 41 women), without other infections, neoplasia, or immunodeficiencies. Although with no difference in age, patients with DAC presented an increase in severity-associated COVID-19 markers such as C-reactive protein (CRP), neutrophil count, and neutrophil-to-lymphocyte ratio. In addition, patients with DAC presented a reduction in the lymphocytes and monocytes counts. Importantly, the DAC group presented an increase in death rate in comparison with the non-DAC group. Our results demonstrated that, in our cohort, DAC enhanced COVID-19-associated inflammation, and increased the number of deaths due to COVID-19. (AU)

Processo FAPESP: 17/18199-9 - Efeito da suplementação materna com o ácido retinoico durante a amamentação na resposta imunológica da prole de camundongos
Beneficiário:Maria Notomi Sato
Linha de fomento: Auxílio à Pesquisa - Regular