| Full text | |
| Author(s): Show less - |
Alberca, Ricardo Wesley
[1]
;
Rigato, Paula Ordonhez
[2]
;
Leuzzi Ramos, Yasmim Alefe
[1]
;
Emidio Teixeira, Franciane Mouradian
[3, 1]
;
Calvielli Branco, Anna Claudia
[3, 1]
;
Fernandes, Iara Grigoletto
[1]
;
Pietrobon, Anna Julia
[3, 1]
;
da Silva Duarte, Alberto Jose
[1]
;
Aoki, Valeria
[1]
;
Orfali, Raquel Leao
[1]
;
Sato, Maria Notomi
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med FMUSP, Inst Med Trop, Dept Dermatol, Lab Dermatol & Imunodeficiencias LI, Sao Paulo - Brazil
[2] Adolfo Lutz Inst, Immunol Ctr, Tech Div Med Biol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | FRONTIERS IN NUTRITION; v. 8, JUN 2 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can generate a systemic disease named coronavirus disease-2019 (COVID-19). Currently, the COVID-19 pandemic has killed millions worldwide, presenting huge health and economic challenges worldwide. Several risk factors, such as age, co-infections, metabolic syndrome, and smoking have been associated with poor disease progression and outcomes. Alcohol drinking is a common social practice among adults, but frequent and/or excessive consumption can mitigate the anti-viral and anti-bacterial immune responses. Therefore, we investigated if patients with self-reported daily alcohol consumption (DAC) presented alteration in the immune response to SARS-CoV-2. We investigated 122 patients with COVID-19 (101 male and 46 females), in which 23 were patients with DAC (18 men and 5 women) and 99 were non-DAC patients (58 men and 41 women), without other infections, neoplasia, or immunodeficiencies. Although with no difference in age, patients with DAC presented an increase in severity-associated COVID-19 markers such as C-reactive protein (CRP), neutrophil count, and neutrophil-to-lymphocyte ratio. In addition, patients with DAC presented a reduction in the lymphocytes and monocytes counts. Importantly, the DAC group presented an increase in death rate in comparison with the non-DAC group. Our results demonstrated that, in our cohort, DAC enhanced COVID-19-associated inflammation, and increased the number of deaths due to COVID-19. (AU) | |
| FAPESP's process: | 17/18199-9 - Effect of maternal supplementation with retinoic acid during breastfeeding on the immune response of mice offspring |
| Grantee: | Maria Notomi Sato |
| Support Opportunities: | Regular Research Grants |