Coronavirus Disease 2019 (COVID-19) and Nutritional Status: The Missing Link?

Autor(es)

Silverio, Renata ^{[1, 2]} ; Goncalves, Daniela Caetano ^{[1, 3]} ; Andrade, Marcia Fabia ^[1] ; Seelaender, Marilia ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo - Brazil

^[2] Univ Fed Santa Catarina, Multictr Grad Program Physiol Sci, Ctr Biol Sci, Florianopolis, SC - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Biosci Dept, Campus Baixada Santista, Santos, SP - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Clin Surg, LIM HC 26, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ADVANCES IN NUTRITION; v. 12, n. 3, p. 682-692, MAY 2021.
• Citações Web of Science: 20

Resumo

Coronavirus disease 2019 (COVID-19) is an emerging disease that has reached pandemic status by rapidly spreading worldwide. Elderly individuals and patients with comorbidities such as obesity, diabetes, and hypertension show a higher risk of hospitalization, severe disease, and mortality by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These patients frequently show exacerbated secretion of proinflammatory cytokines associated with an overreaction of the immune system, the so-called cytokine storm. Host nutritional status plays a pivotal role in the outcome of a variety of different infectious diseases. It is known that the immune system is highly affected by malnutrition, leading to decreased immune responses with consequent augmented risk of infection and disease severity. Body composition, especially low lean mass and high adiposity, has consistently been linked to worsened prognosis in many different diseases. In this review, evidence concerning the impact of nutritional status on viral infection outcomes is discussed. (AU)

• Processo FAPESP: 12/50079-0 - Inflamação sistêmica em pacientes com caquexia associada ao câncer: mecanismos e estratégias terapêuticas, uma abordagem em medicina translacional
• Beneficiário: Marilia Cerqueira Leite Seelaender
• Modalidade de apoio: Auxílio à Pesquisa - Temático