nterplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cance

Autor(es)

Aguayo, Francisco ^[1] ; Boccardo, Enrique ^[2] ; Corvalan, Alejandro ^[3] ; Calaf, Gloria M. ^{[4, 5]} ; Blanco, Rances ^[6]

Afiliação do(s) autor(es)

^[1] Univ Tarapaca, Arica 1000000 - Chile

^[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Lab Oncovirol, Sao Paulo - Brazil

^[3] Pontificia Univ Catolic Chile, Adv Ctr Chron Dis ACCDiS, Santiago - Chile

^[4] Univ Tarapaca, Inst Alta Invest, Arica 1000000 - Chile

^[5] Columbia Univ, Med Ctr, Ctr Radiol Res, New York, NY 10032 - USA

^[6] Univ Chile, Inst Ciencias Biomed ICBM, Fac Med, Programa Virol, Lab Oncovirol, Santiago - Chile

• Tipo de documento: Artigo de Revisão
• Fonte: INFECTIOUS AGENTS AND CANCER; v. 16, n. 1 JUN 30 2021.
• Citações Web of Science: 1

Resumo

Epstein-Barr virus (EBV) is a herpesvirus associated with lymphoid and epithelial malignancies. Both B cells and epithelial cells are susceptible and permissive to EBV infection. However, considering that 90% of the human population is persistently EBV-infected, with a minority of them developing cancer, additional factors are necessary for tumor development. Xenobiotics such as tobacco smoke (TS) components, pollutants, pesticides, and food chemicals have been suggested as cofactors involved in EBV-associated cancers. In this review, the suggested mechanisms by which xenobiotics cooperate with EBV for carcinogenesis are discussed. Additionally, a model is proposed in which xenobiotics, which promote oxidative stress (OS) and DNA damage, regulate EBV replication, promoting either the maintenance of viral genomes or lytic activation, ultimately leading to cancer. Interactions between EBV and xenobiotics represent an opportunity to identify mechanisms by which this virus is involved in carcinogenesis and may, in turn, suggest both prevention and control strategies for EBV-associated cancers. (AU)

• Processo FAPESP: 19/26065-8 - Regulação da expressão e atividade do inibidor de metaloproteinases de matriz RECK por proteínas precoces de papilomavírus humano: impacto no processo de desenvolvimento tumoral
• Beneficiário: Enrique Mario Boccardo Pierulivo
• Modalidade de apoio: Auxílio à Pesquisa - Regular