The biobank of barretos cancer hospital: 14 years of experience in cancer research

Autor(es)

Neuber, Ana Caroline ^[1] ; Tostes, Cassio Hoft ^[1] ; Ribeiro, Adeylson Guimaraes ^[2] ; Marczynski, Gabriella Taques ^[1] ; Komoto, Tatiana Takahasi ^[1] ; Rogeri, Caroline Domingues ^[1] ; da Silva, Vinicius Duval ^{[3, 1]} ; Mauad, Edmundo Carvalho ^[2] ; Reis, Rui Manuel ^{[4, 5, 6, 1]} ; Marques, Marcia M. C. ^{[7, 2, 1]}

Afiliação do(s) autor(es)

^[1] Barretos Canc Hosp Biobank, Sao Paulo - Brazil

^[2] Barretos Canc Hosp, Mol Oncol Res Ctr, Rua Antenor Duarte Vilela 1331, BR-14784400 Barretos, SP - Brazil

^[3] Barretos Canc Hosp, Dept Pathol, Sao Paulo - Brazil

^[4] ICVS 3Bs PT Govt Associate Lab, Braga - Portugal

^[5] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga - Portugal

^[6] Barretos Canc Hosp, Dept Prevent, Barretos - Brazil

^[7] Barretos Sch Hlth Sci, Barretos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CELL AND TISSUE BANKING; JUL 2021.
• Citações Web of Science: 0

Resumo

Despite the developments in cancer research over years, cancer is still one of the leading causes of death worldwide. In Brazil, the number of cancer cases for the several next years (2020-2022) is expected to increase up to 625,000. Thus, translational research has been vital to determine the potential risk, prognostic, and predictive biomarkers in cancer. Therefore, Barretos Cancer Hospital implemented a biobank (BB-BCH) in 2006, which is responsible for processing, storage, and provision of biological materials from cancer and non-cancer participants. Hence, this article aimed to describe BB-BCH's history, experiences, and outcomes and explore its impact on Brazilian translational oncology research scenario. BB-BCH has a multidisciplinary team who are responsible for guaranteeing the quality of all processes as recommended by international guidelines for biobanks. Furthermore, BB-BCH has ample equipment to ensure the quality of all material requested by researchers as genetic material (DNA and RNA) and/or entire biospecimens. From 2006 to 2019, BB-BCH contained 252,069 samples from 44,933 participants, the whole collection is represented by 15 different types of biospecimens collected from them. According to our data, the most collected and stored topography in men is head and neck (29%); in women is breast (28%); and in children is torso and limb (27%) samples. Finally, we supported national and international consortia and projects such as The Cancer Genome Atlas. BB-BCH is a vital knowledge source for scientific community, enabling the development of high-quality studies, with a wide variety of tumor categories and high national representativeness of Brazilian population. (AU)

• Processo FAPESP: 18/22100-0 - Neoplasias malignas nas 18 cidades pertencentes à regional de saúde de Barretos, São Paulo: a importância de um Registro de Câncer de Base Populacional
• Beneficiário: Adeylson Guimarães Ribeiro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado