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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Burkholderia sacchari (synonym Paraburkholderia sacchari): An industrial and versatile bacterial chassis for sustainable biosynthesis of polyhydroxyalkanoates and other bioproducts

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Autor(es):
Oliveira-Filho, Edmar Ramos [1] ; Gomez, Jose Gregorio Cabrera [1] ; Taciro, Marilda Keico [1] ; Silva, Luiziana Ferreira [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Bioresource Technology; v. 337, OCT 2021.
Citações Web of Science: 0
Resumo

This is the first review presenting and discussing Burkholderia sacchari as a bacterial chassis. B. sacchari is a distinguished polyhydroxyalkanoates producer strain, with low biological risk, reaching high biopolymer yields from sucrose (0.29 g/g), and xylose (0.38 g/g). It has great potential for integration into a biorefinery using residues from biomass, achieving 146 g/L cell dry weight containing 72% polyhydroxyalkanoates. Xylitol (about 70 g/L) and xylonic acid {[}about 390 g/L, productivity 7.7 g/(L.h)] are produced by the wild-type B. sacchari. Recombinants were constructed to allow the production and monomer composition control of diverse tailormade polyhydroxyalkanoates, and some applications have been tested. 3-hydroxyvalerate and 3-hydroxyhexanoate yields from substrate reached 80% and 50%, respectively. The genome-scale reconstruction of its metabolic network, associated with the improvement of tools for genetic modification, and metabolic fluxes understanding by future research, will consolidate its potential as a bioproduction chassis. (AU)

Processo FAPESP: 16/00842-0 - Melhoramento da eficiência bacteriana no uso de xilose e co-substratos para produzir biopolímeros a partir de biomassa: engenharia da linhagem, otimização de processo e testes de aplicações
Beneficiário:Luiziana Ferreira da Silva
Modalidade de apoio: Auxílio à Pesquisa - Programa BIOEN - Regular