Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study

Autor(es)

Fossa Shirata, Marina Mendes ^[1] ; Goncalves Maia Campos, Patricia Maria Berardo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Photochemistry and Photobiology; v. 97, n. 4, p. 805-815, JUL 2021.
• Citações Web of Science: 1

Resumo

Photoprotective formulations containing substances with antioxidant properties in combination have been used as a strategy for the improvement of photoaged skin conditions. However, there is a lack of studies evaluating the clinical efficacy of these substances in young women with signs of photoaging. Thus, the objective of the present study was to evaluate the clinical efficacy of sunscreens and cosmetic formulations containing ascorbyl tetraisopalmitate and rice peptides for the improvement of skin photoaging in young women. A double-blind, randomized placebo-controlled clinical efficacy study was conducted on 60 female subjects aged 20-30 years with skin changes related to photoaging and without photoprotective habits. The hydrolipidic layer conditions and structural and morphological characteristics of the skin were evaluated by biophysical and skin imaging techniques. The results showed that the daily use of the formulations under study improved the skin conditions by increasing skin hydration and dermis echogenicity. In addition, the application of the active substances reduced skin hyperpigmentation and increased epidermal cell renewal. In summary, the present study showed the importance of daily application of sunscreens and formulations with antioxidant properties for the prevention and attenuation of skin changes related to photoaging in young women. (AU)

• Processo FAPESP: 17/19278-0 - Desenvolvimento de formulações cosméticas para a pele e cabelos contendo extrato de guaraná e peptídeos de arroz: avaliação da eficácia e das propriedades mecânicas
• Beneficiário: Patrícia Maria Berardo Gonçalves Maia Campos
• Modalidade de apoio: Auxílio à Pesquisa - Regular