Biocompatibility of polyvinyl alcohol/trisodium trimetaphosphate as vitreous substitute in experimental vitrectomy model in rabbits

Autor(es)

de Oliveira, Ramon Antunes ^[1] ; Muralha, Felipe Picanco ^[1] ; Grupenmacher, Alex Treiger ^[1] ; Morandim-Giannetti, Andreia dr Araujo ^[2] ; Bersanetti, Patricia Alessandra ^[3] ; Maia, Mauricio ^[1] ; Magalhaes Junior, Octaviano ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Escola Paulista Med, Sao Paulo - Brazil

^[2] Ctr Univ FEI, Dept Chem Engn, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Biochem, Escola Paulista Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 110, n. 2 JUL 2021.
• Citações Web of Science: 0

Resumo

Synthetic hydrogels have been proposed as vitreous substitutes recently. This study aims to evaluate the biocompatibility of polyvinyl alcohol (PVA) crosslinked with trisodium trimetaphosphate (SMTP) hydrogel in rabbit vitrectomized eyes. Seven animals were submitted to pars plana vitrectomy and the vitreous was replaced by PVA/SMTP hydrogel. Optical coherence tomography, fluorescein angiogram, clinical, and electrophysiological (ERG) examinations were analyzed at baseline, on postoperative days 7 and 30. The fellow eye was used as the control group. Hydrogel opacification was observed and ERG recordings were reduced in the hydrogel group in rod response, b-wave cone response and flicker. A histological analysis showed retinal disorganization, presence of multinucleated cells, and intraretinal hydrogel particles. The PVA/SMTP hydrogel showed poor biocompatibility. Novel biomaterials compounds should be analyzed in vivo. (AU)

• Processo FAPESP: 16/07468-6 - Determinação da biocompatibilidade de hidrogel utilizado na cirurgia vitreorretiniana
• Beneficiário: Octaviano Magalhães Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular