Effects of photobiomodulation therapy on neuropathic pain in rats: evaluation of nociceptive mediators and infrared thermography

Autor(es)

de Oliveira, Mara Evany ^[1] ; Da Silva, Joyce Teixeira ^{[2, 3]} ; Brioschi, Marcos Leal ^[4] ; Chacur, Marucia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Neuroanat Func Dor, Dept Anat, Inst Ciencias Biomed, Av Prof Lineu Prestes 2415, BR-05508900 Sao Paulo, SP - Brazil

^[2] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD - USA

^[3] Univ Maryland, Dept Neural & Pain Sci, Baltimore, MD 21201 - USA

^[4] Univ Sao Paulo, Hosp Clin, Div Neurol, Escola Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 36, n. 7, p. 1461-1467, SEP 2021.
• Citações Web of Science: 0

Resumo

Nerve injury induces release of peptides and upregulation of receptors such as substance P and transient receptor potential receptor V1 (TRPV1), which contribute to the development and maintenance of chronic pain. Photobiomodulation therapy (PBMT) is a nonpharmacological strategy that promotes tissue repair and reduces pain and inflammation. However, the molecular basis for PBMT effects on neuropathic pain is still unclear. We investigated the effects of PBMT on substance P, TRPV1, and superficial temperature change in a rodent model of neuropathic pain. We evaluated substance P and TRPV1 in dorsal root ganglia (DRG L4 to L6) at baseline, 14 days after chronic constriction injury (CCI) and after PBMT. We also assessed the superficial temperature of tarsal, metatarsal, tibia, and fibula regions before and after PBMT using infrared thermography. Substance P and TRPV1 levels increased in DRG of CCI rats compared to naive and sham rats and decreased after PBMT. Infrared thermography showed increased temperature of tarsal, metatarsal, tibia, and fibula regions in CCI rats, which was decreased after PBMT. There were no statistical differences between CCI rats with PBMT, sham, and naive rats in any assay. PBMT reduces nociceptive mediators and hind paw and leg's temperature in a rodent model of neuropathic pain, suggesting that PBMT may play a modulatory role in thermoregulation, neurogenic inflammation, and thermal sensitivity in peripheral nerve injuries. Therefore, PBMT appears to be a valuable strategy for neuropathic pain treatment in clinical settings. (AU)

• Processo FAPESP: 13/01274-7 - Avaliação da radiação LASER AsGa 904nm sobre o processo álgico no modelo de dor neuropática em ratos.
• Beneficiário: Mara Evany de Oliveira Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/20026-6 - Uso do laser de baixa intensidade e os mecanismos celulares e moleculares no processo de reparação no sistema nervoso periférico
• Beneficiário: Daniel de Oliveira Martins
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 12/05840-4 - Mobilização Neural: Avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática
• Beneficiário: Fabio Martinez dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado