Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of photobiomodulation therapy on neuropathic pain in rats: evaluation of nociceptive mediators and infrared thermography

Full text
Author(s):
de Oliveira, Mara Evany [1] ; Da Silva, Joyce Teixeira [2, 3] ; Brioschi, Marcos Leal [4] ; Chacur, Marucia [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Lab Neuroanat Func Dor, Dept Anat, Inst Ciencias Biomed, Av Prof Lineu Prestes 2415, BR-05508900 Sao Paulo, SP - Brazil
[2] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD - USA
[3] Univ Maryland, Dept Neural & Pain Sci, Baltimore, MD 21201 - USA
[4] Univ Sao Paulo, Hosp Clin, Div Neurol, Escola Med, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Lasers in Medical Science; v. 36, n. 7, p. 1461-1467, SEP 2021.
Web of Science Citations: 0
Abstract

Nerve injury induces release of peptides and upregulation of receptors such as substance P and transient receptor potential receptor V1 (TRPV1), which contribute to the development and maintenance of chronic pain. Photobiomodulation therapy (PBMT) is a nonpharmacological strategy that promotes tissue repair and reduces pain and inflammation. However, the molecular basis for PBMT effects on neuropathic pain is still unclear. We investigated the effects of PBMT on substance P, TRPV1, and superficial temperature change in a rodent model of neuropathic pain. We evaluated substance P and TRPV1 in dorsal root ganglia (DRG L4 to L6) at baseline, 14 days after chronic constriction injury (CCI) and after PBMT. We also assessed the superficial temperature of tarsal, metatarsal, tibia, and fibula regions before and after PBMT using infrared thermography. Substance P and TRPV1 levels increased in DRG of CCI rats compared to naive and sham rats and decreased after PBMT. Infrared thermography showed increased temperature of tarsal, metatarsal, tibia, and fibula regions in CCI rats, which was decreased after PBMT. There were no statistical differences between CCI rats with PBMT, sham, and naive rats in any assay. PBMT reduces nociceptive mediators and hind paw and leg's temperature in a rodent model of neuropathic pain, suggesting that PBMT may play a modulatory role in thermoregulation, neurogenic inflammation, and thermal sensitivity in peripheral nerve injuries. Therefore, PBMT appears to be a valuable strategy for neuropathic pain treatment in clinical settings. (AU)

FAPESP's process: 13/01274-7 - Evaluation of LASER radiation AsGa 904nm on pain process in neuropathic pain model in rats.
Grantee:Mara Evany de Oliveira Silva
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/20026-6 - Use of low-level laser and mechanisms in molecular and cellular repair process in peripheral nervous system
Grantee:Daniel de Oliveira Martins
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/05840-4 - Neural Mobilization: molecular and behavioral assessment in rats after induction of neuropathic pain
Grantee:Fabio Martinez dos Santos
Support Opportunities: Scholarships in Brazil - Doctorate